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RNF223 Knockout Cell Lines

Gene: RNF223

Official Full Name: ring finger protein 223provided by HGNC

Gene Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO21336 RNF223 Knockout cell line (HCT 116) Human RNF223 1:2~1:4 Negative Online Inquiry

Background

RNF223 Gene Knockout Cell Lines are genetically engineered cellular models wherein the RNF223 gene has been precisely inactivated using advanced CRISPR-Cas9 technology. This product provides researchers with valuable tools for studying the function of RNF223, a gene implicated in various cellular processes, including regulation of immune response and cellular stress response pathways. By eliminating the function of RNF223, these knockout cell lines allow for the detailed examination of its role in pathological conditions and normal physiology.

The key function of these cell lines is to facilitate the investigation of the biological consequences of RNF223 gene loss. Upon knockout of RNF223, changes in signaling pathways can be monitored, providing insights into the protein's involvement in oncogenesis, autophagy, and protein degradation processes. This capability is crucial for elucidating the molecular mechanisms underlying diseases such as cancer, where RNF223 may play a regulatory role.

The scientific importance of RNF223 Gene Knockout Cell Lines extends to both basic research and clinical applications. In research settings, they enable the dissection of complex biological pathways and gene interactions, contributing to a greater understanding of disease mechanisms. Clinically, these models hold potential for the development of targeted therapies leveraging pathways influenced by RNF223.

What sets our RNF223 Gene Knockout Cell Lines apart is their verified efficiency and specificity of the gene editing, ensuring minimal off-target effects. Compared to conventional methods, such as RNA interference, which may yield transient and incomplete knockdowns, these knockout models provide a stable and definitive approach to gene inactivation. This stability is crucial for long-term studies and offers reproducible results, enhancing confidence in data interpretation.

For researchers and clinicians seeking to delve deeply into gene function studies or therapeutic innovations, RNF223 Gene Knockout Cell Lines present indispensable resources. These cell lines are supported by comprehensive documentation and a commitment to technical support, reinforcing our company’s dedication to advancing scientific research through cutting-edge biological products. Our expertise in genetic engineering and molecular biology consistently enables us to meet the evolving needs of the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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