Gene: RNF123
Official Full Name: ring finger protein 123provided by HGNC
Gene Summary: The protein encoded by this gene contains a C-terminal RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions, and an N-terminal SPRY domain. This protein displays E3 ubiquitin ligase activity toward the cyclin-dependent kinase inhibitor 1B which is also known as p27 or KIP1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
GP00607 | RNF123 gRNA1-gRNA2 KO plasmid | RNF123 | $850 | |||
KO00605 | RNF123 Knockout cell line (HCT 116) | Human | RNF123 | 1:2~1:4 | Negative | Online Inquiry |
KO00831 | RNF123 Knockout cell line(HEK293) | Human | RNF123 | 1:3~1:6 | Negative | Online Inquiry |
KO14476 | RNF123 Knockout cell line (HeLa) | Human | RNF123 | 1:3~1:6 | Negative | Online Inquiry |
KO14477 | RNF123 Knockout cell line (A549) | Human | RNF123 | 1:3~1:4 | Negative | Online Inquiry |
RNF123 Gene Knockout Cell Lines are advanced biological research tools designed to facilitate the study of gene function and regulation by specifically disabling the RNF123 gene. These expertly crafted cell lines are engineered using CRISPR-Cas9 technology, a revolutionary genome-editing method that allows for precise modifications of the DNA sequence. By rendering the RNF123 gene non-functional, researchers can observe downstream effects on cellular pathways, protein interactions, and overall cellular behavior, thereby uncovering insights into the biological roles this gene plays in various physiological and pathological contexts.
The key function of RNF123 Gene Knockout Cell Lines lies in their ability to mimic disease states or genetic conditions, allowing scientists to investigate the roles of RNF123 in cell proliferation, apoptosis, and other critical biological processes. This enables researchers to conduct in-depth studies into the implications of RNF123 dysregulation in diseases such as cancer, neurodegenerative disorders, and metabolic syndromes. In clinical settings, these cell lines can serve as valuable models to test therapeutic interventions aimed at modulating the effects of RNF123.
What sets RNF123 Gene Knockout Cell Lines apart from other gene editing tools is their highly specific targeting, which significantly reduces off-target effects and enhances experimental reproducibility. Compared to traditional knockout methods, CRISPR-mediated knockout offers a faster, more efficient means to generate consistent cell line models that maintain relevant cellular characteristics. Moreover, these cell lines are meticulously validated for functionality and stability, ensuring that researchers can rely on their performance in various experimental conditions.
For researchers and clinicians seeking to deepen their understanding of gene function or develop novel therapeutic strategies, RNF123 Gene Knockout Cell Lines represent an invaluable resource. Their application can accelerate the pace of discovery in biomedical research, offering insights that can lead to breakthroughs in treatment approaches or novel drug development.
With years of expertise in providing high-quality biological products, our company is committed to equipping the scientific community with reliable tools like the RNF123 Gene Knockout Cell Lines to drive innovation and research excellence.
Please note that all services are for research use only. Not intended for any clinical use.
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