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RNF111 Knockout Cell Lines

Gene: RNF111

Official Full Name: ring finger protein 111provided by HGNC

Gene Summary: The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO14486 RNF111 Knockout cell line (HeLa) Human RNF111 1:3~1:6 Negative Online Inquiry
KO14487 RNF111 Knockout cell line (HCT 116) Human RNF111 1:2~1:4 Negative Online Inquiry
KO14488 RNF111 Knockout cell line (HEK293) Human RNF111 1:3~1:6 Negative Online Inquiry
KO14489 RNF111 Knockout cell line (A549) Human RNF111 1:3~1:4 Negative Online Inquiry

Background

RNF111 Gene Knockout Cell Lines are a cutting-edge tool utilized in molecular biology and genetic research, specifically designed to study the function of the RNF111 gene, a critical player in various cellular processes including cell cycle regulation and DNA damage repair. These cell lines are engineered through CRISPR-Cas9 technology to create precise knockouts, allowing researchers to investigate the downstream effects of RNF111 deletion, unravel molecular mechanisms, and identify potential pathways involved in disease states.

The primary function of RNF111 Gene Knockout Cell Lines is to serve as models for examining alterations in cellular behavior attributed to the absence of the RNF111 gene. This includes assessing how the knockout influences signaling pathways related to proliferation, apoptosis, and genomic stability. By harnessing these cellular models, scientists can perform functional assays, including proliferation assays, Western blots for protein analysis, and gene expression profiling, thereby elucidating the role of RNF111 in tumorigenesis as well as other physiological conditions.

The scientific importance of RNF111 Gene Knockout Cell Lines is underscored by their application in both fundamental and applied research settings. They facilitate studies into the oncogenic potential of RNF111, offering insights that could lead to novel therapeutic strategies for cancers where the gene is implicated. Additionally, these cell lines present a valuable resource for pharmaceutical companies developing targeted therapies, as well as for academic institutions engaged in innovative genetic research.

What sets RNF111 Gene Knockout Cell Lines apart from alternatives is their high specificity and reliability, achieved through the precise editing capabilities of CRISPR technology. Unlike traditional gene silencing methods, which may differ in efficiency and durability, these knockout lines ensure a complete and stable loss of gene function, enabling reproducible results. Moreover, our product is validated against multiple assays, ensuring robust performance across various experimental conditions.

The value of RNF111 Gene Knockout Cell Lines to researchers and clinicians lies in their versatile applications and enhanced capacity to yield new biological insights, ultimately advancing our understanding of genetic regulation and therapeutic interventions. Our company, with a strong commitment to excellence in bioengineering and cellular technologies, provides these state-of-the-art tools backed by rigorous quality control and expert scientific support, ensuring that you receive the highest standards in biological research products.

Please note that all services are for research use only. Not intended for any clinical use.

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