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RNASEL Knockout Cell Lines

Gene: RNASEL

Official Full Name: ribonuclease Lprovided by HGNC

Gene Summary: This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. The protein is involved in innate immunity and is active against multiple RNA viruses, including the influenza and SARS-CoV-2 viruses. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. [provided by RefSeq, Nov 2021]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
GP00644 RNASEL gRNA4-gRNA5 KO plasmid RNASEL $850
KO00834 RNASEL Knockout cell line(293T) Human RNASEL 1:3~1:6 Negative Online Inquiry
KO14490 RNASEL Knockout cell line (HeLa) Human RNASEL 1:3~1:6 Negative Online Inquiry
KO14491 RNASEL Knockout cell line (HCT 116) Human RNASEL 1:2~1:4 Negative Online Inquiry
KO14492 RNASEL Knockout cell line (HEK293) Human RNASEL 1:3~1:6 Negative Online Inquiry
KO14493 RNASEL Knockout cell line (A549) Human RNASEL 1:3~1:4 Negative Online Inquiry

Background

RNASEL Gene Knockout Cell Lines are precisely engineered cellular models designed to facilitate comprehensive exploration of the RNASEL gene's roles in various biological processes, particularly those linked to antiviral responses and tumor suppression. These cell lines have been created using CRISPR/Cas9 gene-editing technology, which allows for the accurate and efficient knockout of the RNASEL gene, resulting in a robust platform for functional studies.

The primary mechanism by which RNASEL influences cellular behavior involves its role in the immune response to viral infections. The RNASEL protein is an endoribonuclease that degrades viral RNA, thus playing a critical role in the innate immune response. By employing these knockout cell lines, researchers can elucidate the molecular pathways influenced by RNASEL depletion, providing insights into not only viral pathogenesis but also tumorigenesis, as RNASEL is believed to have antiproliferative effects on cancer cells.

In both research and clinical settings, these RNASEL Gene Knockout Cell Lines have significant applications. They serve as invaluable tools for studying viral pathogenesis, the development of individualized medicine strategies, and understanding the complexities of cancer biology. Unlike conventional models, these knockout lines offer a specific focus on the functional absence of RNASEL, allowing for clear delineation of its effects on cellular pathways.

One of the unique selling points of our RNASEL Gene Knockout Cell Lines is their precision and reproducibility, enabling researchers to achieve consistent and reliable results. Moreover, the ease of use combined with seamless integration into existing workflows makes them a preferred choice over other models which may present issues of gene expression variability or background activity.

For researchers and clinicians aiming to advance their understanding of RNA-mediated immune responses or investigate potential therapeutic avenues in cancer treatment, RNASEL Gene Knockout Cell Lines provide an essential resource. The potential for discovering novel drug targets and improving patient outcomes is significant.

Backed by years of expertise in genetic engineering and cell line development, our company is dedicated to offering high-quality biological products like the RNASEL Gene Knockout Cell Lines, ensuring that scientists have access to cutting-edge tools to propel their research forward.

Please note that all services are for research use only. Not intended for any clinical use.

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