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RLN2 Knockout Cell Lines

Gene: RLN2

Official Full Name: relaxin 2provided by HGNC

Gene Summary: This gene encodes a member of the relaxin subfamily and insulin superfamily of peptide hormones. In humans there are three non-allelic relaxin genes. This gene encodes multiple protein isoforms, at least one of which undergoes proteolytic processing. This processing generates relaxin A and B chains that are linked by disulfide bonds to form the mature peptide hormone. This hormone plays a role in the male and female reproductive systems and was initially noted for its role in pregnancy. This protein also plays broader roles in the cardiovascular system, including in the regulation of blood pressure and control of heart rate, and data from animal models shows that this protein may have anti-fibrotic and cardioprotective effects. [provided by RefSeq, Jul 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO04351 RLN2 Knockout cell line (HeLa) Human RLN2 1:3~1:6 Negative Online Inquiry
KO04352 RLN2 Knockout cell line (HCT 116) Human RLN2 1:2~1:4 Negative Online Inquiry
KO04353 RLN2 Knockout cell line (HEK293) Human RLN2 1:3~1:6 Negative Online Inquiry
KO04354 RLN2 Knockout cell line (A549) Human RLN2 1:3~1:4 Negative Online Inquiry

Background

RLN2 Gene Knockout Cell Lines are specifically engineered cellular models that enable researchers to study the functional implications of the relaxation factor 2 (RLN2) gene. Gene knockout technologies, such as CRISPR-Cas9, have been employed to create these cell lines, resulting in the complete loss of RLN2 expression. This knockout allows for the investigation of RLN2's role in physiological and pathological processes, particularly in areas related to reproductive biology, fibrosis, and cancer progression.

At the core of the functionality of RLN2 Gene Knockout Cell Lines is their ability to facilitate the analysis of gene function by removing RLN2's influence. Researchers can examine changes in cellular behavior, signaling pathways, and gene expression profiles in the absence of RLN2. This mechanistic understanding can be pivotal for uncovering RLN2’s involvement in various biological responses and conditions.

The scientific importance of these cell lines is underscored by their applications in both basic and translational research. They serve as vital tools for probing the molecular mechanisms underlying diseases associated with altered RLN2 activity, such as uterine fibroids and cardiovascular diseases. In a clinical context, understanding the consequences of RLN2 knockout could lead to innovative therapeutic strategies that target specific pathways influenced by this gene.

Compared to alternative models, RLN2 Gene Knockout Cell Lines offer unparalleled specificity and robustness for studying the direct effects of RLN2 absence. While traditional pharmacological approaches may inadvertently affect multiple targets, these knockouts provide a clearer, more defined view of RLN2's role, thereby enhancing research accuracy.

For researchers and clinicians alike, the value of RLN2 Gene Knockout Cell Lines lies in their capability to yield insights that can accelerate the development of targeted treatments and improve patient outcomes. Our company boasts a commitment to innovation and quality, ensuring that our cell lines meet the highest standards for research applications, thereby empowering scientists in their quest for knowledge in the field of biology and medicine.

Please note that all services are for research use only. Not intended for any clinical use.

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