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RIMS1 Knockout Cell Lines

Gene: RIMS1

Official Full Name: regulating synaptic membrane exocytosis 1provided by HGNC

Gene Summary: The protein encoded by this gene is a RAS gene superfamily member that regulates synaptic vesicle exocytosis. This gene also plays a role in the regulation of voltage-gated calcium channels during neurotransmitter and insulin release. Mutations have suggested a role cognition and have been identified as the cause of cone-rod dystrophy type 7. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO02002 RIMS1 Knockout cell line (HeLa) Human RIMS1 1:3~1:6 Negative Online Inquiry

Background

RIMS1 Gene Knockout Cell Lines are genetically modified cell lines specifically engineered to lack the RIMS1 gene, which encodes for the protein regulating synaptic transmission. These cell lines serve as invaluable tools for studying the physiological and pathological roles of RIMS1 in neurobiology and its broader implications in synaptic function and neurotransmission. Their precise knockout allows researchers to dissect the mechanistic pathways influenced by RIMS1 and to evaluate its interactions with various neurotransmitters and synaptic structures.

The primary function of RIMS1 is to facilitate the release of neurotransmitters at the presynaptic terminal, making these knockout lines pivotal for examining synaptic efficacy and plasticity. By examining these lines, scientists can elucidate the role of RIMS1 in disorders characterized by synaptic dysfunction, such as schizophrenia or autism spectrum disorders. The systematic approach with these cell lines permits the dissection of molecular signaling cascades and the identification of potential therapeutic targets.

In the realm of scientific research and clinical studies, RIMS1 Gene Knockout Cell Lines provide an advanced platform for high-throughput drug screening and in vitro modeling of neurodegenerative diseases. Their unique biological characteristics can reveal insights that traditional cell lines cannot capture, significantly enhancing the understanding of synaptic mechanics and potential interventions.

What sets our RIMS1 Gene Knockout Cell Lines apart is the meticulous approach in gene editing, which ensures high specificity and minimal off-target effects, providing reliable and reproducible results. Compared to alternatives, these cell lines allow for more accurate modeling of RIMS1-related conditions, thereby accelerating the research and discovery process.

Incorporating RIMS1 Gene Knockout Cell Lines into your lab's toolkit will not only empower your research with precision but also facilitate the translation of findings into clinical applications, ultimately leading to improved therapeutic strategies. Our company prides itself on delivering high-quality, rigorously validated biological products, backed by our extensive expertise in gene editing technologies and commitment to advancing life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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