Gene: RGS6
Official Full Name: regulator of G protein signaling 6provided by HGNC
Gene Summary: This gene encodes a member of the RGS (regulator of G protein signaling) family of proteins, which are defined by the presence of a RGS domain that confers the GTPase-activating activity of these proteins toward certain G alpha subunits. This protein also belongs to a subfamily of RGS proteins characterized by the presence of DEP and GGL domains, the latter a G beta 5-interacting domain. The RGS proteins negatively regulate G protein signaling, and may modulate neuronal, cardiovascular, lymphocytic activities, and cancer risk. Many alternatively spliced transcript variants encoding different isoforms with long or short N-terminal domains, complete or incomplete GGL domains, and distinct C-terminal domains, have been described for this gene, however, the full-length nature of some of these variants is not known.[provided by RefSeq, Mar 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO33021 | RGS6 Knockout cell line (HCT 116) | Human | RGS6 | 1:2~1:4 | Negative | Online Inquiry |
RGS6 Gene Knockout Cell Lines are precision-engineered cellular models derived from mammalian cells in which the RGS6 (Regulator of G Protein Signaling 6) gene has been inactivated. This innovative product allows researchers to explore the intricate role of RGS6 in G protein-coupled signaling pathways, a crucial area of study given its implications in various physiological and pathological processes, including cardiac function, neurotransmission, and oncogenesis.
The key function of these knockout cell lines lies in their ability to provide a clear framework for studying the mechanistic roles of RGS6 in cellular signaling. By effectively eliminating RGS6 gene expression, these cell lines help elucidate the downstream effects of G protein signaling in different cellular contexts, enabling researchers to assess the impact of enhanced or diminished RGS activity without interference from endogenous RGS6 protein. The versatility of these models allows for comprehensive investigations across various applications, from drug discovery to disease modeling.
The scientific importance of RGS6 Gene Knockout Cell Lines is underscored by their application in both research and clinical settings. Researchers studying psychiatric disorders, cardiovascular diseases, and cancer can utilize these cell lines to assess how changes in G protein signaling pathways contribute to disease mechanisms, thus facilitating the identification of potential therapeutic targets.
A significant advantage of using RGS6 Gene Knockout Cell Lines over traditional models is their specificity. Unlike chemical inhibitors or RNA interference that may yield off-target effects or incomplete gene suppression, these knockout cell lines provide a robust, reproducible system with total gene inactivation. This specificity enhances the reliability of experimental outcomes and the translation of laboratory results to clinical applications.
For researchers and clinicians, these knockout cell lines present a valuable opportunity to deepen their understanding of G protein signaling pathways, ultimately guiding the development of more effective treatments. Our company brings extensive expertise in gene editing technologies, ensuring that each RGS6 Gene Knockout Cell Line is crafted using rigorous quality control measures and cutting-edge techniques. This commitment to excellence positions us as a trusted provider for those looking to advance their research in the intricate world of cellular signaling.
Please note that all services are for research use only. Not intended for any clinical use.
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