Gene: RAB35
Official Full Name: RAB35, member RAS oncogene familyprovided by HGNC
Gene Summary: Enables GTPase activity and anion binding activity. Involved in several processes, including endosomal transport; plasma membrane to endosome transport; and protein localization to endosome. Located in several cellular components, including clathrin-coated endocytic vesicle; clathrin-coated pit; and intercellular bridge. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO31307 | RAB35 Knockout cell line (HeLa) | Human | RAB35 | 1:3~1:6 | Negative | Online Inquiry |
KO31308 | RAB35 Knockout cell line (HCT 116) | Human | RAB35 | 1:2~1:4 | Negative | Online Inquiry |
KO31309 | RAB35 Knockout cell line (HEK293) | Human | RAB35 | 1:3~1:6 | Negative | Online Inquiry |
KO31310 | RAB35 Knockout cell line (A549) | Human | RAB35 | 1:3~1:4 | Negative | Online Inquiry |
RAB35 Gene Knockout Cell Lines are specialized cellular models engineered to specifically disrupt the expression of the RAB35 gene, a member of the RAS oncogene family known for its role in intracellular trafficking, actin cytoskeletal dynamics, and cellular signaling pathways. These knockout cell lines serve as valuable tools in research, enabling scientists to investigate the functional implications of RAB35 loss, thereby elucidating its contributions to various biological processes and disease states, including cancer and neurological disorders.
The mechanism by which RAB35 gene knockout operates involves the strategic introduction of targeted mutations through CRISPR/Cas9 or other gene editing technologies, effectively silencing the gene's expression. This results in altered cellular behaviors, such as changes in endosomal trafficking and membrane dynamics, allowing researchers to explore downstream effects on cellular physiology. By studying these modifications, scientists can draw insights into the developmental and pathological roles of RAB35.
The scientific importance of RAB35 Gene Knockout Cell Lines extends across diverse applications, from basic research to therapeutic development. In research settings, these cell lines can aid in dissecting the molecular pathways influenced by RAB35, while in clinical settings, they hold promise for identifying potential biomarkers or therapeutic targets in diseases where RAB35 dysregulation is implicated.
Compared to alternatives, RAB35 Gene Knockout Cell Lines are unique in their specificity and ability to model the exact loss-of-function conditions associated with RAB35. They provide a more accurate representation of the gene's biological effects than general inhibitors or overexpression systems.
For researchers and clinicians, the adoption of RAB35 Gene Knockout Cell Lines represents a strategic investment in understanding complex cellular mechanisms. Their unique capabilities make them indispensable for advancing knowledge in developmental biology and therapeutics. Additionally, our company prides itself on its expertise in providing high-quality biological models, bolstered by a commitment to innovation and scientific integrity, thereby ensuring that our products meet the rigorous standards demanded by the scientific community.
Please note that all services are for research use only. Not intended for any clinical use.
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