Gene: RAB17
Official Full Name: RAB17, member RAS oncogene familyprovided by HGNC
Gene Summary: The Rab subfamily of small GTPases plays an important role in the regulation of membrane trafficking. RAB17 is an epithelial cell-specific GTPase (Lutcke et al., 1993 [PubMed 8486736]).[supplied by OMIM, Oct 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO14757 | RAB17 Knockout cell line (HeLa) | Human | RAB17 | 1:3~1:6 | Negative | Online Inquiry |
KO14758 | RAB17 Knockout cell line (HCT 116) | Human | RAB17 | 1:2~1:4 | Negative | Online Inquiry |
RAB17 Gene Knockout Cell Lines are genetically modified cell lines specifically designed to study the role of the RAB17 gene, which encodes a member of the RAB family of small GTPases. These proteins are integral to intracellular vesicle trafficking processes, impacting a variety of cellular functions such as endocytosis, exocytosis, and the maintenance of membrane integrity. By knocking out the RAB17 gene, our cell lines provide a unique model for investigating the gene's contribution to cell signaling pathways, cellular proliferation, and differentiation.
The precise mechanism of action involves a genomic editing technique, typically employing CRISPR/Cas9 technology, to create targeted deletions in the RAB17 gene. This results in the absence of RAB17 protein expression, allowing researchers to observe the resultant phenotypic changes and molecular alterations in cellular behavior. This facilitates deeper insights into the cellular mechanisms underlying various diseases, particularly in cancer research and neurological disorders where RAB proteins are known to play crucial roles.
The scientific significance of RAB17 Gene Knockout Cell Lines extends much further into both basic and applied research. With increasing recognition of the RAB proteins in pharmacological contexts, these knockout models serve as invaluable tools for drug discovery, biomarker validation, and therapeutic development. They enable researchers to screen for compounds that can modulate RAB17-related pathways, laying the groundwork for innovative treatment strategies.
Our RAB17 Gene Knockout Cell Lines stand out due to their verified specificity and efficiency, providing a reliable alternative to other gene manipulation methods that may produce off-target effects. Additionally, our product comes with comprehensive documentation and customer support to ensure seamless integration into ongoing research projects.
By choosing our RAB17 Gene Knockout Cell Lines, researchers and clinicians gain access to high-quality, validated models that enhance experimental rigor and support novel discoveries. Our commitment to excellence in genetic tools and resources stems from years of expertise in biological product development, solidifying our position as a trusted partner in the scientific community.
Please note that all services are for research use only. Not intended for any clinical use.
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