Gene: RAB12
Official Full Name: RAB12, member RAS oncogene familyprovided by HGNC
Gene Summary: Enables GDP binding activity. Predicted to be involved in several processes, including endocytic recycling; endosome to lysosome transport; and positive regulation of macroautophagy. Predicted to act upstream of or within cellular response to type II interferon. Predicted to be located in lysosome; phagocytic vesicle; and recycling endosome membrane. Predicted to be active in cytoplasmic vesicle and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO37350 | RAB12 Knockout cell line (HeLa) | Human | RAB12 | 1:3~1:6 | Negative | Online Inquiry |
KO37351 | RAB12 Knockout cell line (HCT 116) | Human | RAB12 | 1:2~1:4 | Negative | Online Inquiry |
KO37352 | RAB12 Knockout cell line (HEK293) | Human | RAB12 | 1:3~1:6 | Negative | Online Inquiry |
KO37353 | RAB12 Knockout cell line (A549) | Human | RAB12 | 1:3~1:4 | Negative | Online Inquiry |
RAB12 Gene Knockout Cell Lines are genetically engineered cell lines that have had the RAB12 gene specifically disrupted, rendering it nonfunctional. RAB12 is a member of the RAB family of small GTPases, which are pivotal in regulating intracellular transport and membrane trafficking. By knocking out this gene, researchers can investigate the role of RAB12 in cellular processes such as autophagy, vesicle transport, and other critical pathways that impact cell homeostasis and function.
The key mechanism of the RAB12 Gene Knockout Cell Lines lies in their ability to provide a model for analyzing the functional consequences of RAB12 deficiency. This capability allows scientists to study how the absence of RAB12 affects cellular dynamics, protein degradation, and the response to stressors. The research implications are vast—understanding RAB12 pathways could shed light on pathological conditions such as neurodegenerative diseases, cancer progression, and metabolic disorders.
In both research and clinical settings, these knockout cell lines serve as powerful tools to elucidate the molecular underpinnings of diseases and to test therapeutic interventions. The specificity of this product enables detailed investigations into the roles of RAB12 without the interference commonly found in other genetic models.
Compared to alternative models, the RAB12 Gene Knockout Cell Lines offer the advantage of targeted gene disruption, leading to a clearer interpretation of phenotypic changes and biological processes. Additionally, these cell lines are optimized for high reproducibility, making them reliable for experimental validation.
Researchers and clinicians will find significant value in utilizing RAB12 Gene Knockout Cell Lines as they pave the way for innovative discoveries and could potentially assist in developing novel therapeutics targeting associated pathways. Our company prides itself on its commitment to providing high-quality, precise genetic tools and maintaining expertise in the realm of genetic engineering and cellular biology, ensuring our products are backed by rigorous scientific validation.
Please note that all services are for research use only. Not intended for any clinical use.
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