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PURB Knockout Cell Lines

Gene: PURB

Official Full Name: purine rich element binding protein Bprovided by HGNC

Gene Summary: This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO35778 PURB Knockout cell line (HeLa) Human PURB 1:3~1:6 Negative Online Inquiry
KO35779 PURB Knockout cell line (HCT 116) Human PURB 1:2~1:4 Negative Online Inquiry
KO35780 PURB Knockout cell line (HEK293) Human PURB 1:3~1:6 Negative Online Inquiry
KO35781 PURB Knockout cell line (A549) Human PURB 1:3~1:4 Negative Online Inquiry

Background

PURB Gene Knockout Cell Lines are expertly engineered cellular models designed to enable precise functional analyses of the PURB gene, a critical regulator of gene expression and cellular differentiation. These cell lines are created using CRISPR-Cas9 technology to achieve targeted mutations within the PURB gene, leading to its complete knockout. This powerful tool allows researchers to investigate the role of PURB in various biological processes, including neurodevelopment, cancer biology, and cellular response mechanisms.

The primary mechanism of these cell lines involves the disruption of the PURB coding sequence, resulting in a loss of protein function. This effectively allows scientists to explore the cellular consequences of PURB deficiency, elucidating its involvement in transcriptional regulation and signaling pathways. Consequently, researchers can gain insights into the complex networks of gene interactions, identifying potential therapeutic targets or biomarkers for disease.

In research and clinical settings, the PURB Gene Knockout Cell Lines provide unparalleled value. Their applications range from basic biological research to drug discovery and the development of gene therapies. By utilizing these specific knockout models, researchers can streamline their investigations, reducing time and costs associated with preliminary screenings of knockouts in wild-type backgrounds.

What sets our PURB Gene Knockout Cell Lines apart from alternatives is the rigor with which they are developed and validated. Each cell line undergoes extensive characterization, confirming successful knockout functionality and stability. Our commitment to quality ensures reproducibility in experimental results, empowering scientists to confidently build upon their findings.

Choosing our PURB Gene Knockout Cell Lines not only enhances the reliability of research outcomes but also positions scientists at the cutting edge of genetic investigation. With our expertise in biological product development and a strong commitment to supporting the research community, we ensure that our products meet the highest scientific standards, providing researchers and clinicians with the tools they need to advance their work effectively.

Please note that all services are for research use only. Not intended for any clinical use.

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