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PTPN9 Knockout Cell Lines

Gene: PTPN9

Official Full Name: protein tyrosine phosphatase non-receptor type 9provided by HGNC

Gene Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain that shares a significant similarity with yeast SEC14, which is a protein that has phosphatidylinositol transfer activity and is required for protein secretion through the Golgi complex in yeast. This PTP was found to be activated by polyphosphoinositide, and is thought to be involved in signaling events regulating phagocytosis. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO35813 PTPN9 Knockout cell line (HeLa) Human PTPN9 1:3~1:6 Negative Online Inquiry
KO35814 PTPN9 Knockout cell line (HCT 116) Human PTPN9 1:2~1:4 Negative Online Inquiry
KO35815 PTPN9 Knockout cell line (HEK293) Human PTPN9 1:3~1:6 Negative Online Inquiry
KO35816 PTPN9 Knockout cell line (A549) Human PTPN9 1:3~1:4 Negative Online Inquiry

Background

PTPN9 Gene Knockout Cell Lines are genetically modified cell lines in which the PTPN9 (Protein Tyrosine Phosphatase Non-Receptor Type 9) gene has been specifically disrupted or "knocked out." This product serves as a powerful tool in molecular biology research, aimed at elucidating the role of PTPN9 in various cellular processes, including signaling pathways and interactions that are crucial for immune response and cellular proliferation.

The mechanism of action relies on the CRISPR-Cas9 technology, which allows precise alterations to the genome. By completely knocking out the PTPN9 gene, researchers can study the downstream effects of its absence on cellular behavior, particularly in immune cell populations. This knockout model enables the dissection of signal transduction pathways affected by PTPN9, giving insights into its role in diseases, such as cancer and autoimmune disorders.

The scientific importance of PTPN9 Gene Knockout Cell Lines is underscored by their applications in drug discovery, pharmacogenomics, and translational research. They provide a unique platform for testing the efficacy and safety of new therapeutics targeting PTPN9-related pathways, enhancing our understanding of its contributions to disease pathology.

One of the key advantages of using these knockout cell lines is their reproducibility and reliability compared to alternative models, such as siRNA or antisense oligonucleotide techniques, which may not achieve complete gene suppression. Moreover, the stability and ease of handling make these cell lines suitable for high-throughput screening assays and functional studies.

For researchers and clinicians dedicated to advancing our understanding of immunological and oncological processes, PTPN9 Gene Knockout Cell Lines represent an invaluable resource that not only enhances scientific inquiry but also paves the way for innovative therapeutic strategies.

Our company prides itself on delivering high-quality biological products that empower researchers with the tools necessary for groundbreaking discoveries, backed by extensive experience in genetic engineering and cell line development.

Please note that all services are for research use only. Not intended for any clinical use.

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