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PTPN12 Knockout Cell Lines

Gene: PTPN12

Official Full Name: protein tyrosine phosphatase non-receptor type 12provided by HGNC

Gene Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO04153 PTPN12 Knockout cell line (HeLa) Human PTPN12 1:3~1:6 Negative Online Inquiry
KO04154 PTPN12 Knockout cell line (HCT 116) Human PTPN12 1:2~1:4 Negative Online Inquiry
KO04155 PTPN12 Knockout cell line (HEK293) Human PTPN12 1:3~1:6 Negative Online Inquiry
KO04156 PTPN12 Knockout cell line (A549) Human PTPN12 1:3~1:4 Negative Online Inquiry

Background

PTPN12 Gene Knockout Cell Lines represent a groundbreaking tool in molecular and cellular biology, specifically designed to explore the functional roles of the PTPN12 gene, which encodes a protein tyrosine phosphatase involved in numerous signaling pathways. These cell lines are engineered to lack functional PTPN12, facilitating detailed investigations into its involvement in cellular processes such as proliferation, differentiation, and immune regulation. By creating a system without the confounding effects of this gene, researchers can directly assess the downstream impacts on key signaling cascades and identify potential therapeutic targets for diseases associated with dysregulated signaling, such as cancer and autoimmune disorders.

The specificity of the knockout mechanism in these cell lines allows for precise manipulation of the cellular environment, providing invaluable insights into PTPN12-associated pathways. Scientists can utilize these models to conduct drug screening, assess the impact of PTPN12 disruptions on protein interactions, and evaluate phenotypic changes related to cellular behavior. The ability of these cell lines to mimic disease states enhances their utility for translational research and drug development.

When compared to traditional models, such as knockdown approaches using RNA interference, PTPN12 Gene Knockout Cell Lines offer unparalleled specificity; they provide a complete absence of the gene, eliminating residual activity and helping to prevent off-target effects. This leads to more reliable and reproducible results, essential for product validation and regulatory processes in drug development.

Valuable to researchers and clinicians alike, these knockout cell lines serve as a robust platform for cutting-edge studies informing novel therapies and advancing our understanding of PTPN12's role in health and disease. Through innovative product offerings, our company leverages its extensive expertise in custom cellular tools and gene-editing technologies to support your research endeavors, ensuring high-quality resources that contribute significantly to scientific advancement.

Please note that all services are for research use only. Not intended for any clinical use.

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