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PTCHD1 Knockout Cell Lines

Gene: PTCHD1

Official Full Name: patched domain containing 1provided by HGNC

Gene Summary: This gene encodes a membrane protein with a patched domain. The encoded protein is similar to Drosophila proteins which act as receptors for the morphogen sonic hedgehog. Deletions in this gene, which is located on the X chromosome, are associated with intellectual disability and autism (PMID: 21091464, PMID: 20844286). [provided by RefSeq, Aug 2011]

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Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO25975 PTCHD1 Knockout cell line (HEK293) Human PTCHD1 1:3~1:6 Negative Online Inquiry

Background

PTCHD1 Gene Knockout Cell Lines are specialized cell lines developed to facilitate the study of the PTCHD1 gene's role in various biological processes, particularly those pertaining to neural development and function. By utilizing CRISPR/Cas9 genome editing technology, these cell lines have been generated to precisely disrupt the PTCHD1 gene, allowing researchers to observe phenotypic changes and alterations in cellular pathways that are tied to neurodevelopmental disorders.

The key mechanism underpinning the utility of PTCHD1 Knockout Cell Lines involves gene expression analysis, cellular proliferation, and differentiation studies. Researchers can leverage these cell lines to delve into the downstream effects of PTCHD1 loss-of-function, observing related signaling pathways, transcriptional changes, and cellular behaviors pertinent to conditions such as autism spectrum disorders and other neurodevelopmental conditions linked to PTCHD1 dysregulation.

The scientific significance of these cell lines cannot be overstated, as they provide pivotal insights into the molecular underpinnings of neural development and potential therapeutic targets. In clinical settings, this knowledge is instrumental for the identification of biomarkers, drug development, and the exploration of novel treatment strategies for neurodevelopmental disorders.

What sets our PTCHD1 Gene Knockout Cell Lines apart from alternative models is their high fidelity in recapitulating the genetic and phenotypic characteristics associated with PTCHD1 mutations, bolstered by our rigorous validation processes. The precise, targeted disruption of the PTCHD1 gene ensures minimal off-target effects, making these cell lines a reliable choice for researchers seeking to draw meaningful conclusions.

For researchers and clinicians, the value of PTCHD1 Gene Knockout Cell Lines lies in their ability to bridge the gap between basic research and clinical relevance. By providing a robust platform for experimental manipulation, these lines empower users to explore the complexities of neurodevelopment with unprecedented clarity.

Our company has a longstanding commitment to advancing genetic research through precision cellular models, and our PTCHD1 Gene Knockout Cell Lines exemplify our innovation and expertise in this critical area of study. Researchers can trust in our proven track record of delivering high-quality biological products tailored to meet the demands of cutting-edge scientific inquiry.

Please note that all services are for research use only. Not intended for any clinical use.

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