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PTAFR Knockout Cell Lines

Gene: PTAFR

Official Full Name: platelet activating factor receptorprovided by HGNC

Gene Summary: This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO08068 PTAFR Knockout cell line (HCT 116) Human PTAFR 1:2~1:4 Negative Online Inquiry
KO08069 PTAFR Knockout cell line (A549) Human PTAFR 1:3~1:4 Negative Online Inquiry

Background

PTAFR Gene Knockout Cell Lines are specially engineered cell lines that have undergone precision gene editing to create a loss-of-function model for the PTAFR (Platelet-Activating Factor Receptor) gene. This innovative tool allows researchers to study the biological implications of PTAFR in a controlled environment, providing insights into its role in various physiological and pathological processes.

The key mechanism behind PTAFR Gene Knockout Cell Lines involves the CRISPR-Cas9 gene-editing technology, which enables targeted disruption of the PTAFR gene. By preventing the expression of this receptor, researchers can investigate downstream signaling pathways and cellular responses associated with its absence. This is particularly valuable in understanding inflammatory responses, tissue repair, and immune cell modulation, where PTAFR is known to play a critical role.

In scientific research and clinical contexts, these knockout cell lines are invaluable for elucidating the molecular mechanisms underlying diseases associated with dysregulated PTAFR signaling, such as asthma, cardiovascular diseases, and certain cancers. By employing these models, researchers can identify potential therapeutic targets and assess the efficacy of new pharmacological agents aimed at modulating this receptor.

What sets PTAFR Gene Knockout Cell Lines apart from alternative products is their customization and the rigor of the gene-editing process, which ensures a reliable and reproducible model. Moreover, these cell lines come with in-depth validation data to support their use in experimental setups, offering an outstanding tool for both researchers and developers in academia and industry.

The value of PTAFR Gene Knockout Cell Lines lies not only in their ability to advance basic science but also in their potential to bridge the gap between laboratory findings and clinical applications. By utilizing these cell lines, researchers can significantly boost their studies' efficiency and relevance to human health outcomes.

As a leader in the development of advanced biological products, our company is committed to delivering high-quality, cutting-edge tools that empower scientists and clinicians alike to drive discovery and innovation in their respective fields.

Please note that all services are for research use only. Not intended for any clinical use.

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