Home / PSME1 Knockout Cell Lines

PSME1 Knockout Cell Lines

Gene: PSME1

Official Full Name: proteasome activator subunit 1provided by HGNC

Gene Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the alpha subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to form a heterohexameric ring. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO04616 PSME1 Knockout cell line (HeLa) Human PSME1 1:3~1:6 Negative Online Inquiry
KO04617 PSME1 Knockout cell line (HCT 116) Human PSME1 1:2~1:4 Negative Online Inquiry
KO04618 PSME1 Knockout cell line (HEK293) Human PSME1 1:3~1:6 Negative Online Inquiry
KO04619 PSME1 Knockout cell line (A549) Human PSME1 1:3~1:4 Negative Online Inquiry

Background

PSME1 Gene Knockout Cell Lines represent a powerful tool for elucidating the role of the PSME1 gene in various biological processes. These engineered cell lines have undergone precise genetic modifications to disable the PSME1 gene, allowing researchers to study the gene's functions by observing the resulting phenotypic changes. This approach deepens our understanding of cellular pathways and mechanisms, providing critical insights into cellular responses to stress and immune signaling.

The primary function of PSME1 is linked to the regulation of the immunoproteasome, playing a vital role in the degradation of damaged or misfolded proteins that would otherwise accumulate and disrupt cellular homeostasis. By utilizing the PSME1 knockout cell lines, researchers can explore the downstream effects of this disruption, leading to significant revelations about protein homeostasis, immune responses, and potential implications in diseases such as autoimmune disorders and cancer.

In terms of scientific importance, these cell lines are invaluable for both basic research and translational studies. They facilitate experiments aimed at drug discovery and therapeutic interventions, particularly in targeting the proteasome pathway. By providing a reliable model system, they allow for high-throughput screening of compounds that may modulate immune responses or enhance protein degradation mechanisms, which is essential in developing effective treatments.

One of the key advantages of PSME1 Gene Knockout Cell Lines is the specificity of the knockout technology employed, ensuring minimal off-target effects compared to traditional genetic modification methods. This precision enables researchers to draw more accurate conclusions about the role of PSME1 without the confounding influence of other genetic variations. Furthermore, the cell lines are compatible with various applications, including CRISPR screening and drug efficacy studies, which enhances their utility in a diverse array of research settings.

For researchers and clinicians focused on understanding complex biological systems, the PSME1 Gene Knockout Cell Lines provide unmatched value. They not only accelerate the push towards novel therapeutic discoveries but also enhance the overall understanding of immune-related pathologies, making them indispensable tools in the quest for biomedical advancements.

With a strong commitment to advancing genetic research, our company offers a range of high-quality biological products designed to empower researchers and clinicians alike. We leverage cutting-edge technology and expertise in genetic engineering, ensuring that our products meet the rigorous standards of modern scientific inquiry.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.