Gene: PROC
Official Full Name: protein C, inactivator of coagulation factors Va and VIIIaprovided by HGNC
Gene Summary: This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO05922 | PROC Knockout cell line (HeLa) | Human | PROC | 1:3~1:6 | Negative | Online Inquiry |
KO05923 | PROC Knockout cell line (A549) | Human | PROC | 1:3~1:4 | Negative | Online Inquiry |
PROC Gene Knockout Cell Lines are specially developed cellular models characterized by the targeted disruption of specific genes through advanced gene-editing technologies such as CRISPR/Cas9. These cell lines enable researchers to study gene function, elucidate disease mechanisms, and evaluate the therapeutic potential of novel compounds. By generating precision gene knockout models, each cell line uniquely represents a specific genetic alteration, facilitating the investigation of gene interactions and signaling pathways in both physiological and pathological states.
The primary mechanism behind PROC Gene Knockout Cell Lines involves the use of programmable nucleases that introduce double-strand breaks at predetermined locations within the genome. This targeted approach leads to in-frame or out-of-frame deletions, effectively rendering the targeted gene non-functional. By employing these knockout models, researchers can directly observe phenotypic changes, enabling more in-depth studies of gene roles in cellular processes such as proliferation, differentiation, and response to therapies.
The scientific importance of PROC Gene Knockout Cell Lines extends across multiple research domains, including cancer biology, neurodegenerative disorders, and metabolic diseases. These models are invaluable in drug discovery and development, where validation of target genes and pathways significantly impacts the efficacy and safety of therapeutic candidates in clinical settings.
What sets PROC Gene Knockout Cell Lines apart from traditional models is their exceptional precision and reproducibility. Unlike older methods of gene disruption, which may result in off-target effects or variable expression, PROC cell lines are meticulously validated, ensuring reliability in experimental outcomes. This enhancement in accuracy is crucial for yielding reproducible and transferable data, fostering greater confidence in research findings.
For researchers and clinicians seeking to advance their work in understanding genetic contributions to disease, PROC Gene Knockout Cell Lines offer unparalleled value. They not only streamline experimental workflows but also amplify the quality of scientific inquiry, directly contributing to advancements in precision medicine and personalized therapeutics.
As a leader in innovative biological products, our company combines expertise in genomic technologies with a commitment to supporting the scientific community through high-quality, reliable research tools like PROC Gene Knockout Cell Lines, ultimately driving breakthroughs that contribute to enhanced healthcare solutions.
Please note that all services are for research use only. Not intended for any clinical use.
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