Gene: PRKCB
Official Full Name: protein kinase C betaprovided by HGNC
Gene Summary: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO11011 | PRKCB Knockout cell line (HeLa) | Human | PRKCB | 1:3~1:6 | Negative | Online Inquiry |
KO11012 | PRKCB Knockout cell line (HEK293) | Human | PRKCB | 1:3~1:6 | Negative | Online Inquiry |
PRKCB Gene Knockout Cell Lines are genetically modified cell lines specifically designed to lack the protein kinase C beta (PRKCB) gene, an essential component in various cellular signaling pathways. These cell lines serve as valuable tools for studying the role of PRKCB in physiological and pathological processes, such as signal transduction, cell differentiation, and apoptosis. By enabling researchers to observe the effects of PRKCB deletion, these lines help to elucidate mechanisms underlying diseases such as cancer, diabetes, and cardiovascular disorders.
The primary function of PRKCB in cellular signaling is to mediate the effects of various growth factors and hormones through phosphorylation of target proteins. In the absence of PRKCB, researchers can assess compensatory signaling pathways or alternative routes of cell signaling that may become activated—a crucial aspect in understanding disease mechanisms and developing targeted therapies. These knockout models also allow for the evaluation of gene-gene interactions and the identification of potential biomarkers for disease progression.
In terms of scientific importance, PRKCB Gene Knockout Cell Lines are pivotal in preclinical research, aiding in drug development and validating therapeutic targets. In clinical settings, findings from studies using these cell lines can directly inform treatment strategies, particularly in personalized medicine.
Unlike conventional cell lines, PRKCB knockout variants provide researchers with a nuanced understanding of signaling pathways involved in disease, allowing for more precise experimental outcomes. This specificity supports hypothesis-driven research and enhances the reproducibility of experiments.
For researchers and clinicians targeting the intricacies of signal transduction or investigating therapeutics for related diseases, the PRKCB Gene Knockout Cell Lines represent an invaluable resource. They offer unique insights into PRKCB's function, distinguishing your studies from those reliant on less definitive models.
Our company specializes in the development and provision of high-quality genetic tools and cell lines, backed by extensive expertise in molecular biology and genetics. We are committed to advancing research through innovative solutions that facilitate groundbreaking discoveries in biomedical science.
Please note that all services are for research use only. Not intended for any clinical use.
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