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PPP1R16A Knockout Cell Lines

Gene: PPP1R16A

Official Full Name: protein phosphatase 1 regulatory subunit 16Aprovided by HGNC

Gene Summary: Myosin light chain kinase and phosphatase (MLCP) complexes control the phosphorylation states of regulatory myosin light chains, which is crucial for muscle and intracellular movement. MLCPs typically contain a catalytic protein phosphatase 1 (PP1c) subunit, a myosin phosphatase targeting (MYPT) subunit, and another smaller subunit. The protein encoded by this gene represents an MYPT subunit, which is responsible for directing PP1c to its intended targets. However, while the phosphorylation of other MYPT members results in PP1c inactivation, phosphorylation of the encoded protein by protein kinase A results in PP1c activation. [provided by RefSeq, Jan 2020]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO02871 PPP1R16A Knockout cell line (HeLa) Human PPP1R16A 1:3~1:6 Negative Online Inquiry
KO02872 PPP1R16A Knockout cell line (HCT 116) Human PPP1R16A 1:2~1:4 Negative Online Inquiry
KO02873 PPP1R16A Knockout cell line (HEK293) Human PPP1R16A 1:3~1:6 Negative Online Inquiry
KO02874 PPP1R16A Knockout cell line (A549) Human PPP1R16A 1:3~1:4 Negative Online Inquiry

Background

PPP1R16A Gene Knockout Cell Lines are highly specialized cellular models designed to facilitate the investigation of the PPP1R16A gene's role in various biological processes. These cell lines have been meticulously engineered to have the PPP1R16A gene inactivated, enabling researchers to study the functional implications of its absence in a controlled environment.

The key functions of these knockout cell lines include the examination of cellular signaling pathways, gene expression profiles, and the impact on cellular proliferation and differentiation. By utilizing techniques such as CRISPR-Cas9 gene editing, these cell lines provide a means to elucidate the mechanistic pathways in which PPP1R16A is involved, particularly in contexts such as cancer research, neurobiology, and stress response pathways.

Scientifically, the development of PPP1R16A knockout models is crucial for advancing our understanding of diseases associated with dysregulated protein phosphatase activity. Given the gene's involvement in critical cellular processes, its knockout may reveal novel insights into therapeutic targets or biomarkers for specific diseases. These models have significant applications in both basic and applied research, including drug discovery, pathway analysis, and the development of personalized medicine approaches.

The distinct advantages of PPP1R16A Gene Knockout Cell Lines lie in their validated genetic modification and the high specificity with which they have been developed. Compared to other gene disruption methods, which may yield variable results, these knockout lines offer researchers consistent and reproducible data, reinforcing the validity of experimental outcomes.

In conclusion, PPP1R16A Gene Knockout Cell Lines represent a vital tool for researchers and clinicians aiming to explore the complexities of cellular functions influenced by the PPP1R16A gene. Their sophisticated design and reliability make them an indispensable resource for advancing scientific knowledge and therapeutic advancements. Our company excels in providing high-quality biological models, ensuring reliability and precision in every product we offer to the research community.

Please note that all services are for research use only. Not intended for any clinical use.

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