Gene: PPP1R14A
Official Full Name: protein phosphatase 1 regulatory inhibitor subunit 14Aprovided by HGNC
Gene Summary: The protein encoded by this gene belongs to the protein phosphatase 1 (PP1) inhibitor family. This protein is an inhibitor of smooth muscle myosin phosphatase, and has higher inhibitory activity when phosphorylated. Inhibition of myosin phosphatase leads to increased myosin phosphorylation and enhanced smooth muscle contraction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Sep 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO22045 | PPP1R14A Knockout cell line (A549) | Human | PPP1R14A | 1:3~1:4 | Negative | Online Inquiry |
PPP1R14A Gene Knockout Cell Lines are specialized cell lines engineered to specifically lack the expression of the PPP1R14A gene, which encodes a regulatory protein involved in modulating protein phosphatase 1 (PP1) activity. These cell lines serve as a crucial tool for studying the role of PPP1R14A in cellular signaling pathways and various physiological processes, including cell cycle regulation, cell migration, and apoptosis.
The primary mechanism of action involves the disruption of normal protein function that occurs due to the absence of the PPP1R14A protein. By utilizing these knockout cell lines, researchers can elucidate the consequences of PPP1R14A loss on cellular functions and understand its potential contributions to diseases, such as cancer or cardiovascular disorders. This allows for a deeper exploration of molecular mechanisms and the identification of novel therapeutic targets.
In the context of scientific research, the availability of accurate gene knockout models such as the PPP1R14A cell lines is invaluable for the development of target-specific interventions and is pivotal for advancing gene therapy approaches. Furthermore, these knockout models provide an experimental environment that mimics pathological states, facilitating the testing of pharmacological agents and understanding drug resistance interactions.
What sets our PPP1R14A Gene Knockout Cell Lines apart from alternatives is the stringent validation process they undergo, ensuring high quality and reproducibility in experimental outcomes. These cell lines are generated using state-of-the-art CRISPR/Cas9 gene-editing technology, which guarantees precision and minimizes off-target effects, thereby enhancing the reliability of research findings.
Researchers and clinicians will find our PPP1R14A Gene Knockout Cell Lines essential for advancing their studies, paving the way for new discoveries in cell biology and disease mechanisms. The product's relevance extends across applied biomedical research and clinical applications, making it an indispensable component of any laboratory seeking to innovate or expand their work in cell signaling pathways.
With a commitment to excellence, our company specializes in providing high-quality biological products, leveraging cutting-edge technologies to deliver innovative solutions that meet the evolving needs of the scientific community.
Please note that all services are for research use only. Not intended for any clinical use.
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