Gene: PLSCR4
Official Full Name: phospholipid scramblase 4provided by HGNC
Gene Summary: Enables CD4 receptor binding activity and enzyme binding activity. Predicted to be involved in plasma membrane phospholipid scrambling. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO15017 | PLSCR4 Knockout cell line (HeLa) | Human | PLSCR4 | 1:3~1:6 | Negative | Online Inquiry |
KO15018 | PLSCR4 Knockout cell line (HCT 116) | Human | PLSCR4 | 1:2~1:4 | Negative | Online Inquiry |
KO15019 | PLSCR4 Knockout cell line (A549) | Human | PLSCR4 | 1:3~1:4 | Negative | Online Inquiry |
PLSCR4 Gene Knockout Cell Lines are engineered cellular models designed to delete or "knock out" the PLSCR4 gene, a critical player in various cellular processes such as apoptosis, inflammation, and immune response regulation. This genetic modification allows researchers to study the specific roles and downstream effects associated with the absence of PLSCR4, offering insights into its functions in health and disease.
The mechanism of action for these knockout cell lines involves the use of CRISPR/Cas9 technology, which facilitates precise genome editing. This advanced tool enables the targeted disruption of the PLSCR4 gene, thus providing a clean model for investigating the gene's functions and interactions within cellular pathways. By utilizing these knockout models, scientists can elucidate the gene's contributions to pathophysiological conditions, including cancers and autoimmune diseases.
The scientific importance of PLSCR4 Gene Knockout Cell Lines is underscored by their applicability in both basic and applied research settings. They serve as vital tools for exploring gene function, validating drug targets, and developing novel therapeutic strategies. Such models are instrumental in preclinical studies and enhance the understanding of the molecular mechanisms underlying diseases.
Compared to traditional models that often involve non-specific inhibition or silencing techniques, PLSCR4 Gene Knockout Cell Lines offer the advantage of specificity and reproducibility. Researchers benefit from consistent genetic backgrounds and reduced off-target effects, thus improving the reliability of experimental outcomes.
For researchers, clinicians, and biopharmaceutical companies, these knockout cell lines are invaluable resources that streamline experimental processes and enhance data accuracy. They afford the opportunity to derive actionable insights into disease mechanisms and develop more effective therapies.
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