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PLIN3 Knockout Cell Lines

Gene: PLIN3

Official Full Name: perilipin 3provided by HGNC

Gene Summary: Mannose 6-phophate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs, and is required for endosome-to-Golgi transport. This protein also binds directly to the GTPase RAB9 (RAB9A), a member of the RAS oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO32119 PLIN3 Knockout cell line (HeLa) Human PLIN3 1:3~1:6 Negative Online Inquiry
KO32120 PLIN3 Knockout cell line (HCT 116) Human PLIN3 1:2~1:4 Negative Online Inquiry
KO32121 PLIN3 Knockout cell line (HEK293) Human PLIN3 1:3~1:6 Negative Online Inquiry
KO32122 PLIN3 Knockout cell line (A549) Human PLIN3 1:3~1:4 Negative Online Inquiry

Background

PLIN3 Gene Knockout Cell Lines are specifically engineered cellular models wherein the perilipin 3 gene (PLIN3) has been inactivated through precise gene editing techniques. These cell lines are essential for studying lipid metabolism, lipolysis, and cellular energy regulation, providing researchers with a powerful tool to investigate the roles of lipid droplets and their associated proteins in various physiological and pathological conditions.

The primary function of PLIN3 Gene Knockout Cell Lines lies in their ability to delineate the impact of PLIN3 deficiency on lipid storage and mobilization. By disrupting the PLIN3 gene, these cell lines allow for the observation of altered lipid droplet morphology and dynamics, alongside changes in cellular metabolism. PLIN3 serves as a crucial regulator of lipid droplet stability and function, and its knockout leads to significant insights into processes such as obesity, diabetes, and metabolic syndrome.

Scientifically, these cell lines are invaluable in both research and clinical applications. Researchers can utilize PLIN3 knockout cells to explore the mechanisms underlying lipid-related disorders, potentially leading to the identification of new therapeutic targets. Clinical applications may also arise as understanding PLIN3's contribution to disease processes can facilitate the development of treatments for metabolic diseases linked to dysregulated lipid homeostasis.

Compared to similar products, our PLIN3 Gene Knockout Cell Lines stand out due to their rigorous validation and customization options, which meet the specific needs of diverse research projects. The knockout efficiency is thoroughly characterized, ensuring researchers receive highly reliable models. Furthermore, our commitment to quality and precision distinguishes our offering in a competitive market.

This product is a valuable asset for researchers and clinicians focused on metabolic pathways, providing clarity in understanding lipolysis and energy expenditure. Our company boasts extensive expertise in cellular model development, ensuring each cell line is produced with the utmost scientific rigor and attention to detail, contributing to advancements in biological research.

Please note that all services are for research use only. Not intended for any clinical use.

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