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PLEKHN1 Knockout Cell Lines

Gene: PLEKHN1

Official Full Name: pleckstrin homology domain containing N1provided by HGNC

Gene Summary: Enables phospholipid binding activity. Involved in 3'-UTR-mediated mRNA destabilization; positive regulation of apoptotic process; and response to hypoxia. Located in cytoskeleton and mitochondrial membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO25234 PLEKHN1 Knockout cell line (HeLa) Human PLEKHN1 1:3~1:6 Negative Online Inquiry
KO25235 PLEKHN1 Knockout cell line (HCT 116) Human PLEKHN1 1:2~1:4 Negative Online Inquiry
KO25236 PLEKHN1 Knockout cell line (HEK293) Human PLEKHN1 1:3~1:6 Negative Online Inquiry
KO25237 PLEKHN1 Knockout cell line (A549) Human PLEKHN1 1:3~1:4 Negative Online Inquiry

Background

PLEKHN1 Gene Knockout Cell Lines are customized cellular models engineered for the precise deletion of the PLEKHN1 gene, which encodes a member of the pleckstrin homology domain-containing protein family. These cell lines serve as vital tools for investigating the biological roles of PLEKHN1 in various cellular processes, including cell signaling, cytoskeletal dynamics, and immune responses. By utilizing CRISPR/Cas9 gene editing technology, these knockout lines exhibit a complete absence of PLEKHN1 protein expression, providing an effective means to study gene function and associated pathways.

The primary mechanism underlying the functionality of these knockout cell lines lies in the targeted disruption of the PLEKHN1 gene. This creates an authentic in vitro environment to analyze loss-of-function phenotypes in controlled experimental settings. As researchers explore the implications of PLEKHN1 in pathophysiological conditions, such as cancer and autoimmune diseases, these cell lines facilitate the elucidation of its role in disease progression and therapeutic responses.

The scientific importance of PLEKHN1 Gene Knockout Cell Lines extends to both basic and applied research. In clinical settings, these models can be used to screen for potential therapeutic targets, enabling a better understanding of PLEKHN1-related pathways and contributing to the development of innovative treatment strategies. Their applications range from studies in cell biology to high-throughput drug screening.

What sets these knockout cell lines apart from conventional models is their high specificity and reproducibility, offering researchers a more consistent and reliable outcome. With user-friendly protocols and a robust data set showcasing functional validation, these PLEKHN1 Gene Knockout Cell Lines are indispensable for scientists seeking to disrupt gene function effectively without the confounding effects seen in less precise tools.

Investing in PLEKHN1 Gene Knockout Cell Lines means empowering research with cutting-edge resources that simplify complex gene-function studies and support a variety of experimental designs. Our company brings years of expertise in producing high-quality biological products, ensuring researchers have access to reliable tools essential for advancing their scientific endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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