Gene: PLEK2
Official Full Name: pleckstrin 2provided by HGNC
Gene Summary: The protein encoded by this gene associates with membrane-bound phosphatidylinositols generated by phosphatidylinositol 3-kinase. The encoded protein then interacts with the actin cytoskeleton to induce cell spreading. In conjunction with complement component 1, q subcomponent, B chain (C1QB), this gene shows an increase in expression in melanoma cells and may serve as an accurate biomarker for the disease. [provided by RefSeq, Dec 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO28096 | PLEK2 Knockout cell line (HeLa) | Human | PLEK2 | 1:3~1:6 | Negative | Online Inquiry |
KO28097 | PLEK2 Knockout cell line (HCT 116) | Human | PLEK2 | 1:2~1:4 | Negative | Online Inquiry |
KO28098 | PLEK2 Knockout cell line (HEK293) | Human | PLEK2 | 1:3~1:6 | Negative | Online Inquiry |
KO28099 | PLEK2 Knockout cell line (A549) | Human | PLEK2 | 1:3~1:4 | Negative | Online Inquiry |
PLEK2 Gene Knockout Cell Lines are sophisticated biological research tools designed for the detailed study of the PLEK2 gene, which encodes a protein involved in cytoskeletal dynamics and cellular signaling pathways. These cell lines are engineered to lack functional PLEK2, allowing researchers to dissect its role in various physiological and pathological contexts. Utilizing the CRISPR/Cas9 gene-editing technology, these knockout cells provide a reliable model to investigate the gene’s contributions to cell morphology, migration, and interaction with other cellular components.
The primary function of the PLEK2 knockout cell lines lies in their ability to elucidate the mechanistic pathways influenced by PLEK2, allowing for targeted studies on cancer, immune responses, and neurodegenerative disorders. By comparing cellular behaviors in the PLEK2-deficient lines to wild-type control cells, researchers can glean insights into molecular interactions and signal transduction processes critical for maintaining cellular homeostasis.
Scientifically, these knockout cell lines hold significant importance in advancing our understanding of gene function in complex biological systems. They are invaluable for drug discovery, genetic research, and diagnostic developments. Moreover, their application spans various fields, including oncology and immunology, making them suitable for both basic and applied research.
What sets our PLEK2 Gene Knockout Cell Lines apart from alternatives is their validated performance and reproducibility in experimental setups. Each line comes with detailed characterization data, ensuring researchers can confidently employ these models in their studies. Additionally, our commitment to providing comprehensive customer support and protocols enhances the user experience, facilitating effective experimentation.
In summary, our PLEK2 Gene Knockout Cell Lines represent a significant advancement for researchers and clinicians keen on exploring the depths of gene function. Backed by cutting-edge technology and a deep understanding of molecular biology, our products are designed to meet the rigorous demands of scientific investigation, positioning our company as a leader in providing high-quality biological tools for the research community.
Please note that all services are for research use only. Not intended for any clinical use.
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