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PLCD1 Knockout Cell Lines

Gene: PLCD1

Official Full Name: phospholipase C delta 1provided by HGNC

Gene Summary: This gene encodes a member of the phospholipase C family. Phospholipase C isozymes play critical roles in intracellular signal transduction by catalyzing the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers diacylglycerol (DAG) and inositol triphosphate (IP3). The encoded protein functions as a tumor suppressor in several types of cancer, and mutations in this gene are a cause of hereditary leukonychia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO08039 PLCD1 Knockout cell line (HeLa) Human PLCD1 1:3~1:6 Negative Online Inquiry
KO08040 PLCD1 Knockout cell line (HCT 116) Human PLCD1 1:2~1:4 Negative Online Inquiry
KO08041 PLCD1 Knockout cell line (HEK293) Human PLCD1 1:3~1:6 Negative Online Inquiry
KO08042 PLCD1 Knockout cell line (A549) Human PLCD1 1:3~1:4 Negative Online Inquiry

Background

PLCD1 Gene Knockout Cell Lines are precisely engineered cellular models that have had the phospholipase C delta 1 (PLCD1) gene completely inactivated through cutting-edge genome-editing techniques. This strategic knockout allows researchers to investigate the functional implications of PLCD1 in various biological processes, such as cellular signaling cascades, cellular proliferation, and apoptosis. By understanding the specific roles that PLCD1 plays, scientists can glean insights into its involvement in diseases ranging from cancer to developmental disorders.

The key function of PLCD1 involves the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2), leading to the production of inositol trisphosphate (IP3) and diacylglycerol (DAG), secondary messengers that are pivotal in various signaling pathways. With the knockout cell lines, the absence of PLCD1 facilitates thorough investigations into its contribution to these signaling networks and their physiological outcomes. This feature makes these cell lines invaluable for studying therapeutic targets, drug development, and the molecular mechanisms underlying specific conditions.

The scientific significance of using PLCD1 Gene Knockout Cell Lines extends to both research and clinical applications. In research, these models can be utilized to validate hypotheses about signal transduction and elucidate the pathogenesis of diseases associated with aberrant PLCD1 activity. Clinically, insights garnered from these studies can inform potential biomarker discovery and therapeutic interventions, paving the way for advancements in personalized medicine.

What differentiates PLCD1 Gene Knockout Cell Lines from other cell models is the specificity and precision of the gene-editing technology used in their creation, which ensures high purity and reproducibility of experimental results. Unlike alternative methods that may provide ambiguous insights, these knockout lines produce clear, interpretable data, making them an essential tool for researchers aiming to derive meaningful conclusions from their studies.

For researchers and clinicians alike, the value of PLCD1 Gene Knockout Cell Lines lies not only in their capacity to accelerate discovery and innovation but also in their integration into existing experimental frameworks without the need for extensive recalibration. These products are backed by our company’s profound expertise in cellular and molecular biology, providing quality assurance and technical support that enable users to maximize the potential of their research endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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