Gene: PKN3
Official Full Name: protein kinase N3provided by HGNC
Gene Summary: Predicted to enable protein serine/threonine kinase activity. Involved in epithelial cell migration. Predicted to be located in Golgi apparatus; cytosol; and nucleus. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO10193 | PKN3 Knockout cell line (HeLa) | Human | PKN3 | 1:3~1:6 | Negative | Online Inquiry |
KO10194 | PKN3 Knockout cell line (HCT 116) | Human | PKN3 | 1:2~1:4 | Negative | Online Inquiry |
KO10195 | PKN3 Knockout cell line (HEK293) | Human | PKN3 | 1:3~1:6 | Negative | Online Inquiry |
KO10196 | PKN3 Knockout cell line (A549) | Human | PKN3 | 1:3~1:4 | Negative | Online Inquiry |
PKN3 Gene Knockout Cell Lines are specifically engineered cellular models in which the PKN3 gene, implicated in various signaling pathways related to cell proliferation and survival, has been selectively disrupted or “knocked out.” This innovative tool allows researchers to study the direct effects of PKN3 loss on cellular behavior, enabling a deeper understanding of its role in oncogenesis and other pathologies.
The knockout of the PKN3 gene sheds light on its involvement in key cellular mechanisms such as actin cytoskeleton organization, mitotic progression, and cellular responses to growth factors. Utilizing CRISPR-Cas9 technology or RNA interference methodologies, these cell lines provide a precise model for dissecting PKN3's functions, offering insights into signal transduction pathways that impact cancer progression and neurodegenerative diseases.
Scientifically, PKN3 Gene Knockout Cell Lines hold significant importance in both research and clinical settings. They facilitate investigations into the molecular underpinnings of diseases, thus contributing to the development of targeted therapies aimed at conditions where PKN3 is essential. Their application extends to drug discovery, allowing for high-throughput screening in a controlled environment that mimics physiological conditions.
Compared to traditional knockdown methods, these knockout lines offer greater specificity and reproducibility, raising the bar for experimental accuracy. Researchers benefit from a robust model that clearly delineates PKN3's contributions, minimizing off-target effects common with other methodologies.
For researchers and clinicians alike, PKN3 Gene Knockout Cell Lines present an invaluable resource, fostering breakthroughs in understanding disease mechanisms and therapeutic developments. By investing in these advanced cell lines, users can enhance their research fidelity and accelerate innovation in the field.
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Please note that all services are for research use only. Not intended for any clinical use.
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