Gene: PEAR1
Official Full Name: platelet endothelial aggregation receptor 1provided by HGNC
Gene Summary: PEAR1 is a platelet receptor that signals upon the formation of platelet-platelet contacts independent of platelet activation and secondary to platelet aggregation (Nanda et al., 2005 [PubMed 15851471]).[supplied by OMIM, Mar 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO20748 | PEAR1 Knockout cell line (HeLa) | Human | PEAR1 | 1:3~1:6 | Negative | Online Inquiry |
KO20749 | PEAR1 Knockout cell line (HCT 116) | Human | PEAR1 | 1:2~1:4 | Negative | Online Inquiry |
KO20750 | PEAR1 Knockout cell line (A549) | Human | PEAR1 | 1:3~1:4 | Negative | Online Inquiry |
PEAR1 Gene Knockout Cell Lines represent a significant advancement in genetic research by providing a controlled environment to study the effects of the PEAR1 gene, which is implicated in platelet aggregation and cardiovascular disease. These cell lines have been engineered to lack functional PEAR1 genes, enabling researchers to examine the physiological and pathological roles of this gene in a variety of biological processes.
Key functions of the PEAR1 Gene Knockout Cell Lines include the ability to model cardiovascular conditions by observing the resultant alterations in platelet behavior. The knockout mechanism involves precise gene editing techniques, such as CRISPR-Cas9, allowing for specific deletions that facilitate a deeper understanding of protein interactions and signaling pathways that affect thrombus formation and vascular health. This model not only aids in elucidating the role of PEAR1 in normal hemostasis but also contributes to the exploration of therapeutic targets for clotting disorders and cardiovascular diseases.
In scientific research and clinical settings, these knockout cell lines are indispensable tools for drug discovery, testing the efficacy of novel anticoagulant and antiplatelet therapies, and understanding patient-specific responses to existing treatments. When compared to traditional cell models, which may express varying levels of PEAR1, the knockout lines provide consistency, reproducibility, and a clear framework for interpreting data related to PEAR1 functions.
The advantages of using PEAR1 Gene Knockout Cell Lines include their ability to provide a clear and unambiguous phenotype concerning the effects of the PEAR1 gene, streamlining the research process for investigators focused on cardiovascular health. The ability to directly manipulate and analyze the cellular responses in a controlled manner is invaluable, making this product a critical asset for researchers and clinicians who require precision in their studies.
As a leader in the field of genetic tools and cellular assays, our company is committed to providing high-quality, innovative products that empower researchers and clinicians. We understand the intricacies of cellular mechanisms and are dedicated to supporting groundbreaking discoveries in the arena of molecular biology and medicine.
Please note that all services are for research use only. Not intended for any clinical use.
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