PCSK1 Knockout Cell Lines

Gene: PCSK1

Official Full Name: proprotein convertase subtilisin/kexin type 1provided by HGNC

Gene Summary: This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to subcellular compartments where a second autocatalytic even takes place and the catalytic activity is acquired. The protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic activation of polypeptide hormones and neuropeptides precursors. Mutations in this gene have been associated with susceptibility to obesity and proprotein convertase 1/3 deficiency. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene [provided by RefSeq, Jan 2014]

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Products Background

Products

Catalog Number	Product Name	Species	Gene	Passage ratio	Mycoplasma testing	Price
KO36185	PCSK1 Knockout cell line (HeLa)	Human	PCSK1	1:3~1:6	Negative	Online Inquiry

Background

PCSK1 Gene Knockout Cell Lines are engineered cellular models specifically designed to study the physiological and pathological roles of the proprotein convertase subtilisin/kexin type 1 (PCSK1) gene. This gene is integral in the processing of peptide precursors essential for various biological functions, including insulin maturation and neuropeptide generation. By utilizing CRISPR/Cas9 gene-editing technology, these cell lines exhibit a complete knockout of the PCSK1 gene, allowing researchers to investigate the resultant phenotypic changes and signaling pathways affected by its absence.

The primary function of the PCSK1 Gene Knockout Cell Lines is to provide a robust framework for understanding the implications of PCSK1 loss in cellular processes. These models enable the study of metabolic disorders, such as obesity and diabetes, by facilitating the investigation of altered signaling mechanisms that arise from disrupted insulin processing. Furthermore, these cell lines are invaluable in evaluating potential therapeutic targets for conditions linked to PCSK1 dysfunction, presenting an opportunity for drug discovery and development.

In both research and clinical settings, the scientific importance of these knockout cell lines is undeniable. They serve as critical tools for elucidating the role of PCSK1 in endocrine function and neurobiology. Compared to conventional models, our PCSK1 Gene Knockout Cell Lines offer a clearer and more controlled environment for studying gene function, as they eliminate background interference from wild-type gene expression.

Distinct advantages include their ease of use in high-throughput screening applications and compatibility with various assays, making them suitable for a wide range of experimental protocols. Moreover, provided with extensive validation and characterized performance data, these cell lines enhance the reliability of experimental outcomes, significantly benefiting researchers and clinicians alike.

Our commitment to advancing scientific discovery is reflected in the innovative design and rigorous development of our PCSK1 Gene Knockout Cell Lines. Supported by a team of experts in cellular biology and genetics, we aim to empower researchers with reliable tools for groundbreaking studies in gene function and therapeutic exploration.

Please note that all services are for research use only. Not intended for any clinical use.

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