Gene: OVOL2
Official Full Name: ovo like zinc finger 2provided by HGNC
Gene Summary: This gene encodes a member of the evolutionarily conserved ovo-like protein family. Mammalian members of this family contain a single zinc finger domain composed of a tetrad of C2H2 zinc fingers with variable N- and C-terminal extensions that contain intrinsically disordered domains. Members of this family are involved in epithelial development and differentiation. Knockout of this gene in mouse results in early embryonic lethality with phenotypes that include neurectoderm expansion, impaired vascularization, and heart anomalies. In humans, allelic variants of this gene have been associated with posterior polymorphous corneal dystrophy. [provided by RefSeq, Apr 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO01429 | OVOL2 Knockout cell line(MCF7) | Human | OVOL2 | 1:2~1:4 | Negative | Online Inquiry |
KO15419 | OVOL2 Knockout cell line (HCT 116) | Human | OVOL2 | 1:2~1:4 | Negative | Online Inquiry |
KO15420 | OVOL2 Knockout cell line (HEK293) | Human | OVOL2 | 1:3~1:6 | Negative | Online Inquiry |
OVOL2 Gene Knockout Cell Lines are genetically modified cellular models specifically designed to investigate the biological roles of the OVOL2 (Ovo-like 2) gene. This product features a series of cell lines wherein the OVOL2 gene has been systematically disrupted, enabling researchers to explore the gene's function in various biological processes. OVOL2 is a transcription factor implicated in critical developmental pathways, particularly in epithelial cell differentiation and tumorigenesis, making it a significant target for both basic research and therapeutic interventions.
These knockout cell lines leverage CRISPR/Cas9 technology, a highly precise and efficient genome-editing mechanism, to achieve the knockout. This enables the study of OVOL2's role in cellular mechanisms such as cell fate determination, proliferation, and apoptosis, elucidating its contributions to cancer biology and tissue homeostasis. The functionally knocked-out OVOL2 can serve as a powerful tool for researchers aiming to dissect cellular signaling pathways and enhance drug discovery efforts.
The scientific importance of OVOL2 Gene Knockout Cell Lines is underscored by their broad applications. In research settings, these cell lines are indispensable for dissecting the genetic and molecular underpinnings of diseases where OVOL2 plays a pivotal role. In clinical settings, they hold potential for identifying novel biomarkers and therapeutic targets, paving the way for advancements in personalized medicine.
Compared to conventional methods such as RNA interference (RNAi), OVOL2 gene knockout offers a more robust and permanent alteration of the gene, facilitating more reliable results. Furthermore, these cell lines are compatible with high-throughput screening processes, enhancing experimental throughput and efficiency.
The value of OVOL2 Gene Knockout Cell Lines to researchers and clinicians cannot be overstated. They provide an unparalleled opportunity to uncover the complexity of gene function and its implications for disease. By employing these models, users can contribute to a deeper understanding of the genetic basis of various conditions and potentially identify new treatment avenues.
Our company is dedicated to providing high-quality, innovative biological products backed by extensive expertise in genomic technologies. We are committed to empowering scientific discovery through our precise gene editing solutions, ensuring that researchers and clinicians have access to the best tools for their transformative work.
Please note that all services are for research use only. Not intended for any clinical use.
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