Gene: OR10J4
Official Full Name: olfactory receptor family 10 subfamily J member 4 (gene/pseudogene)provided by HGNC
Gene Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jan 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO15460 | OR10J4 Knockout cell line (HeLa) | Human | OR10J4 | 1:3~1:6 | Negative | Online Inquiry |
KO15461 | OR10J4 Knockout cell line (HCT 116) | Human | OR10J4 | 1:2~1:4 | Negative | Online Inquiry |
KO15462 | OR10J4 Knockout cell line (HEK293) | Human | OR10J4 | 1:3~1:6 | Negative | Online Inquiry |
KO15463 | OR10J4 Knockout cell line (A549) | Human | OR10J4 | 1:3~1:4 | Negative | Online Inquiry |
The OR10J4 Gene Knockout Cell Lines are specialized cellular models that have been engineered to lack the OR10J4 gene, which encodes for a receptor involved in the detection of specific odorant molecules. This product is pivotal for researchers investigating the functional roles of the OR10J4 gene in sensory perception, as well as its potential implications in various neurological and physiological processes.
The key mechanism behind these knockout cell lines involves CRISPR-Cas9 technology, which facilitates precise gene editing. By specifically targeting and deactivating the OR10J4 gene, these cell lines enable scientists to study the subsequent effects on cellular signaling pathways, gene expression profiles, and the overall impact on cell behavior under various stimuli. This makes the lines invaluable for research areas such as olfactory signaling, neurobiology, and pharmacology.
In research and clinical settings, OR10J4 knockout cell lines hold significant importance as they provide a robust platform for drug discovery, toxicology studies, and elucidating the molecular mechanisms of disease. These models allow for the screening of compounds that may interact with the olfactory system or alter the function of related pathways, thus offering insights that could lead to novel therapeutic strategies.
One of the unique advantages of using OR10J4 Gene Knockout Cell Lines is their specificity and reliability compared to traditional cell culture models. Unlike generalized models, these knockout lines have eliminated variability associated with gene expression, enabling reproducibility and accuracy in experimental outcomes. Furthermore, their ease of use in high-throughput screening assays positions them as a superior option for time-sensitive research.
Overall, the value of OR10J4 Gene Knockout Cell Lines is underscored by their capacity to enhance understanding of gene function and its implications in health and disease. This product is an essential tool for researchers and clinicians aiming to push the boundaries of biological science. Our company prides itself on expertise in genetic engineering and high-quality cellular models, ensuring that we deliver products that empower advancements in research and clinical applications.
Please note that all services are for research use only. Not intended for any clinical use.
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