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OAZ1 Knockout Cell Lines

Gene: OAZ1

Official Full Name: ornithine decarboxylase antizyme 1provided by HGNC

Gene Summary: The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs; and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization. Alternatively spliced transcript variants have also been noted for this gene. [provided by RefSeq, Dec 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO05669 OAZ1 Knockout cell line (HeLa) Human OAZ1 1:3~1:6 Negative Online Inquiry
KO05670 OAZ1 Knockout cell line (HCT 116) Human OAZ1 1:2~1:4 Negative Online Inquiry
KO05671 OAZ1 Knockout cell line (HEK293) Human OAZ1 1:3~1:6 Negative Online Inquiry
KO05672 OAZ1 Knockout cell line (A549) Human OAZ1 1:3~1:4 Negative Online Inquiry

Background

OAZ1 Gene Knockout Cell Lines are genetically engineered mammalian cell lines in which the OAZ1 gene, involved in polyamine metabolism, has been disrupted through targeted homologous recombination or CRISPR/Cas9 technology. These knockout models are invaluable for studying the role of OAZ1 in cellular processes, including cell proliferation, differentiation, and stress response, providing insights into the intricate regulatory mechanisms that govern normal cellular function and pathological states.

By specifically silencing the OAZ1 gene, these cell lines allow researchers to investigate the resultant phenotypic changes, elucidating the gene's contribution to polyamine synthesis and metabolic pathways. OAZ1 has been implicated in various physiological and disease contexts, including cancer, neurodegenerative disorders, and immune responses. This makes the availability of OAZ1 knockout models crucial for the research community, as they can serve as a platform for understanding the gene's role in disease mechanisms and for testing potential therapeutic interventions.

Compared to other gene-editing tools or cell lines, OAZ1 Gene Knockout Cell Lines offer unique advantages such as the fidelity of gene disruption, the possibility of generating stable and reproducible research results, and the ease of use for subsequent molecular assays and therapeutic studies. Their specificity ensures that off-target effects are minimized, enhancing the reliability of experimental outcomes.

The value of this product extends far beyond academic research; it can significantly impact pharmaceutical development, enabling researchers to screen drugs targeting polyamine metabolism effectively. The OAZ1 Gene Knockout Cell Lines are thus not only essential for basic research in cell biology but also for applied clinical research, paving the way for innovative therapeutic strategies.

At our company, we pride ourselves on our expertise in genetic engineering and cellular biology, offering a robust catalog of high-quality biological products designed to support researchers and clinicians in advancing scientific knowledge and therapeutic advancements. Our commitment to innovation ensures that you have access to state-of-the-art tools essential for your groundbreaking research.

Please note that all services are for research use only. Not intended for any clinical use.

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