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NUP37 Knockout Cell Lines

Gene: NUP37

Official Full Name: nucleoporin 37provided by HGNC

Gene Summary: Nuclear pore complexes (NPCs) are used for transporting macromolecules between the cytoplasm and the nucleus. NPCs consist of multiple copies of 30 distinct proteins (nucleoporins), which assemble into biochemically-separable subcomplexes. The protein encoded by this gene is part of a subcomplex (Nup107-160) that is required for proper NPC function as well as for normal kinetochore-microtubule interaction and mitosis. [provided by RefSeq, Dec 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO15571 NUP37 Knockout cell line (HeLa) Human NUP37 1:3~1:6 Negative Online Inquiry
KO15572 NUP37 Knockout cell line (HCT 116) Human NUP37 1:2~1:4 Negative Online Inquiry
KO15573 NUP37 Knockout cell line (HEK293) Human NUP37 1:3~1:6 Negative Online Inquiry
KO15574 NUP37 Knockout cell line (A549) Human NUP37 1:3~1:4 Negative Online Inquiry

Background

NUP37 Gene Knockout Cell Lines represent a cutting-edge research tool designed to facilitate the functional exploration of the NUP37 gene, a critical component of the nuclear pore complex. These cell lines are generated using advanced CRISPR-Cas9 gene editing technology, effectively disrupting the NUP37 gene to create a loss-of-function model. This knockout feature allows researchers to investigate the gene's role in nuclear transport, cellular signaling, and its implications in various pathological conditions, such as cancer and viral infections.

The primary function of NUP37 involves its participation in the assembly and maintenance of the nuclear pore complex, which regulates the exchange of molecules between the nucleus and the cytoplasm. By utilizing our NUP37 gene knockout cell lines, researchers can elucidate the pathways influenced by NUP37, facilitating insights into mechanisms of disease and potential therapeutic targets. This is particularly valuable in developing strategies to mitigate diseases associated with nuclear pore complex dysfunction.

Compared to alternative models, our NUP37 knockout cell lines offer superior specificity and efficiency, allowing for robust and reproducible results. While many existing models rely on transient knockdowns or pharmacological inhibitors, our gene knockout approach provides a stable system for prolonged studies, reducing variability in experimental outcomes. Moreover, the versatility of these cell lines enables their use in diverse assays, from high-throughput screening to in-depth molecular analysis.

For researchers and clinicians, the ability to study the NUP37 gene in a controlled environment provides invaluable insights into fundamental biological processes and disease mechanisms. This product is essential for advancing our understanding of nuclear dynamics and developing novel therapeutic strategies.

Our company specializes in providing high-quality biological products, backed by extensive research expertise and a commitment to supporting the scientific community. With our NUP37 Gene Knockout Cell Lines, we empower researchers to unlock new avenues in the study of molecular biology and therapeutic intervention.

Please note that all services are for research use only. Not intended for any clinical use.

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