Gene: NTAN1
Official Full Name: N-terminal asparagine amidaseprovided by HGNC
Gene Summary: The protein encoded by this gene functions in a step-wise process of protein degradation through the N-end rule pathway. This protein acts as a tertiary destabilizing enzyme that deamidates N-terminal L-Asn residues on proteins to produce N-terminal L-Asp. L-Asp substrates are subsequently conjugated to L-Arg, which is recognized by specific E3 ubiquitin ligases and targeted to the proteasome. Pseudogenes of this gene are located on the long arms of chromosomes 8, 10 and 12. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO28667 | NTAN1 Knockout cell line (HeLa) | Human | NTAN1 | 1:3~1:6 | Negative | Online Inquiry |
KO28668 | NTAN1 Knockout cell line (HCT 116) | Human | NTAN1 | 1:2~1:4 | Negative | Online Inquiry |
KO28669 | NTAN1 Knockout cell line (HEK293) | Human | NTAN1 | 1:3~1:6 | Negative | Online Inquiry |
KO28670 | NTAN1 Knockout cell line (A549) | Human | NTAN1 | 1:3~1:4 | Negative | Online Inquiry |
NTAN1 Gene Knockout Cell Lines are specialized laboratory models designed to facilitate the study of the NTAN1 gene, which encodes a protein involved in various cellular processes, including RNA metabolism and cellular stress responses. These cell lines are generated through advanced CRISPR-Cas9 gene-editing technology, which precisely disables the NTAN1 gene, allowing researchers to examine the physiological and molecular effects of its loss.
The key function of the NTAN1 Gene Knockout Cell Lines lies in their ability to create a controlled experimental environment where the consequences of NTAN1 gene deletion can be studied. The knockout of NTAN1 disrupts normal cellular functions, leading to insights into its role in disease pathways, stress responses, and other crucial biological processes. Understanding the mechanisms by which NTAN1 influences cell behavior is vital for uncovering new therapeutic targets.
This product proves invaluable in both research and clinical settings, serving as a tool for drug discovery, mechanistic studies of disease, and the evaluation of potential therapeutic interventions. Its applications extend to cancer research, neurobiology, and regenerative medicine, making it an essential model for investigators in these fields.
Compared to alternative approaches, such as RNA interference or traditional knockout techniques, NTAN1 Gene Knockout Cell Lines provide a more stable and enduring genetic modification, eliminating potential off-target effects and allowing for more robust experimental outcomes. Additionally, the use of CRISPR-Cas9 technology ensures a reliable and reproducible model that contributes to the validity of research findings.
Researchers and clinicians can derive significant value from utilizing these cell lines, as they provide a unique opportunity to dissect complex biological systems, contributing to the advancement of scientific knowledge and the development of innovative therapies.
Our company specializes in delivering high-quality biological products tailored to meet the needs of cutting-edge research. With a commitment to excellence and scientific rigor, we ensure that our offerings, including NTAN1 Gene Knockout Cell Lines, empower scientists to achieve their research goals.
Please note that all services are for research use only. Not intended for any clinical use.
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