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NR2C2 Knockout Cell Lines

Gene: NR2C2

Official Full Name: nuclear receptor subfamily 2 group C member 2provided by HGNC

Gene Summary: This gene encodes a protein that belongs to the nuclear hormone receptor family. Members of this family act as ligand-activated transcription factors and function in many biological processes such as development, cellular differentiation and homeostasis. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes. The protein encoded by this gene plays a role in protecting cells from oxidative stress and damage induced by ionizing radiation. The lack of a similar gene in mouse results in growth retardation, severe spinal curvature, subfertility, premature aging, and prostatic intraepithelial neoplasia (PIN) development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO02919 NR2C2 Knockout cell line (HeLa) Human NR2C2 1:3~1:6 Negative Online Inquiry
KO02920 NR2C2 Knockout cell line (HCT 116) Human NR2C2 1:2~1:4 Negative Online Inquiry
KO02921 NR2C2 Knockout cell line (HEK293) Human NR2C2 1:3~1:6 Negative Online Inquiry
KO02922 NR2C2 Knockout cell line (A549) Human NR2C2 1:3~1:4 Negative Online Inquiry

Background

NR2C2 Gene Knockout Cell Lines are engineered cellular models that feature targeted disruptions of the NR2C2 gene, also known as Nuclear Receptor Subfamily 2 Group C Member 2. This specific modification enables researchers to investigate the biological roles and mechanisms associated with this transcription factor, which is implicated in various physiological processes, including lipid metabolism, immune response, and cellular differentiation.

The key function of these cell lines revolves around elucidating the pathways mediated by NR2C2, allowing for in-depth studies on gene expression regulation. By employing CRISPR-Cas9 technology, the NR2C2 gene is effectively knocked out, which leads to a loss of function that can be analyzed in comparison to wild-type counterparts. This provides a powerful tool for researchers seeking to understand the gene's involvement in diseases such as metabolic disorders, inflammation, and certain cancers.

The scientific importance of NR2C2 Gene Knockout Cell Lines extends to both basic and applied research. In cellular and molecular biology, these models enable the dissection of molecular pathways and identification of potential therapeutic targets, thus facilitating drug development processes. In clinical research, understanding NR2C2's role can contribute to personalized medicine approaches, where therapeutic strategies are tailored based on individual genetic profiles.

What sets our NR2C2 Gene Knockout Cell Lines apart from alternatives is the rigor of our engineering process, ensuring high specificity and efficiency in gene editing. These cell lines are validated through rigorous assays to confirm the knockout effect, providing users with reliable data for their studies. Furthermore, our product adheres to the highest ethical standards and regulatory compliance, offering peace of mind to researchers and clinicians.

For scientists in academia or industry, the value of our NR2C2 Gene Knockout Cell Lines lies in their ability to accelerate discovery and innovation, ultimately contributing to advancements in knowledge that can lead to novel therapeutic interventions. Our commitment to excellence in biological products is backed by years of expertise and a robust portfolio, positioning our company as a trusted partner in cutting-edge research and biotechnology.

Please note that all services are for research use only. Not intended for any clinical use.

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