Gene: NKD1
Official Full Name: NKD inhibitor of WNT signaling pathway 1provided by HGNC
Gene Summary: In the mouse, Nkd is a Dishevelled (see DVL1; MIM 601365)-binding protein that functions as a negative regulator of the Wnt (see WNT1; MIM 164820)-beta-catenin (see MIM 116806)-Tcf (see MIM 602272) signaling pathway.[supplied by OMIM, Jun 2003]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO11726 | NKD1 Knockout cell line (HCT 116) | Human | NKD1 | 1:2~1:4 | Negative | Online Inquiry |
KO11727 | NKD1 Knockout cell line (HEK293) | Human | NKD1 | 1:3~1:6 | Negative | Online Inquiry |
NKD1 Gene Knockout Cell Lines are specialized biological tools designed for the study of the NKD1 gene, which encodes a negative regulator of the Wnt signaling pathway. This gene knockout allows researchers to explore the intricate roles NKD1 plays in cellular processes, such as proliferation, differentiation, and apoptosis. By disabling the NKD1 gene, scientists can analyze downstream effects and gain insights into pathologies related to aberrant Wnt signaling, which is implicated in various cancers and developmental disorders.
The mechanism of action behind these cell lines is straightforward; through targeted gene editing technologies, such as CRISPR-Cas9, the NKD1 gene is rendered nonfunctional. This creates a controlled environment in which researchers can study the consequences of NKD1 loss, particularly how it influences Wnt pathway activation. As Wnt signaling is a critical regulator of many physiological processes, these knockout cell lines serve as an invaluable asset in both basic and applied research.
In clinical and research settings, NKD1 gene knockout cell lines are essential for elucidating the biological mechanisms underpinning Wnt-related diseases. Their importance extends to drug discovery, where understanding the Wnt signaling pathway can contribute to the development of novel therapeutics targeting specific cancer types. Researchers can leverage these cell lines to screen potential compounds that rescue or exacerbate the effects of NKD1 loss, thereby identifying new therapeutic strategies.
What sets our NKD1 Gene Knockout Cell Lines apart from alternatives is the precision and reliability of our gene editing techniques, coupled with extensive validation processes. These lines are produced in a lab environment that prioritizes quality control, ensuring that users receive consistent and reproducible results.
Moreover, the expertise of our company in genetic engineering and cell line development ensures that researchers and clinicians can trust in the dependability and performance of our products. We are committed to supporting scientific inquiry with tools that facilitate deeper understanding of complex biological pathways, making our NKD1 Gene Knockout Cell Lines an essential addition to any research toolkit.
Please note that all services are for research use only. Not intended for any clinical use.
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