Gene: NFU1
Official Full Name: NFU1 iron-sulfur cluster scaffoldprovided by HGNC
Gene Summary: This gene encodes a protein that is localized to mitochondria and plays a critical role in iron-sulfur cluster biogenesis. The encoded protein assembles and transfers 4Fe-4S clusters to target apoproteins including succinate dehydrogenase and lipoic acid synthase. Mutations in this gene are a cause of multiple mitochondrial dysfunctions syndrome-1, and pseudogenes of this gene are located on the short arms of chromosomes 1 and 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO27716 | NFU1 Knockout cell line (HeLa) | Human | NFU1 | 1:3~1:6 | Negative | Online Inquiry |
KO27717 | NFU1 Knockout cell line (HCT 116) | Human | NFU1 | 1:2~1:4 | Negative | Online Inquiry |
KO27718 | NFU1 Knockout cell line (HEK293) | Human | NFU1 | 1:3~1:6 | Negative | Online Inquiry |
KO27719 | NFU1 Knockout cell line (A549) | Human | NFU1 | 1:3~1:4 | Negative | Online Inquiry |
NFU1 Gene Knockout Cell Lines are engineered cellular models designed to study the biological functions of the NFU1 gene, which plays a critical role in the biosynthesis of iron-sulfur clusters essential for mitochondrial function and cellular metabolism. These cell lines have been generated through advanced CRISPR/Cas9 genome editing techniques, ensuring specific and reliable disruption of the NFU1 gene, thus enabling researchers to explore the consequences of NFU1 deficiency on cellular processes, including energy metabolism, oxidative stress responses, and overall cell viability.
The key mechanism underlying the utility of NFU1 Gene Knockout Cell Lines lies in the ability to dissect the molecular pathways affected by the absence of this gene. By utilizing these knockout models, scientists can examine changes in mitochondrial dynamics, assess the impact on cellular respiration, and investigate compensatory mechanisms that might emerge in response to NFU1 loss. This research is particularly vital in the context of disorders related to mitochondrial dysfunction and is applicable to a range of fields, from basic biological research to drug development targeting metabolic diseases.
One of the standout advantages of NFU1 Gene Knockout Cell Lines is their specificity and reliability compared to other models such as RNA interference techniques that may not achieve complete gene knockdown. Additionally, these knockout lines allow for the observation of both acute and chronic effects of NFU1 loss, providing comprehensive insights into its biological roles. The use of knockout models also aligns well with regulatory guidelines in drug development, facilitating translational research into clinical applications.
For researchers and clinicians alike, NFU1 Gene Knockout Cell Lines offer a powerful tool for advancing our understanding of mitochondrial biology and its implications in human disease. The precision of these models enhances the potential for groundbreaking discoveries in therapeutic strategies targeting mitochondrial-related diseases, ranging from neurodegenerative conditions to age-related disorders.
Our company specializes in producing high-quality biological products, and we are committed to equipping researchers with innovative tools that facilitate significant breakthroughs in science and medicine. Our expertise in gene editing technologies ensures that our NFU1 Gene Knockout Cell Lines are not only reliable but also optimized for research applications across various disciplines.
Please note that all services are for research use only. Not intended for any clinical use.
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