Gene: NEXN
Official Full Name: nexilin F-actin binding proteinprovided by HGNC
Gene Summary: This gene encodes a filamentous actin-binding protein that may function in cell adhesion and migration. Mutations in this gene have been associated with dilated cardiomyopathy, also known as CMD1CC. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO23424 | NEXN Knockout cell line (HeLa) | Human | NEXN | 1:3~1:6 | Negative | Online Inquiry |
KO23425 | NEXN Knockout cell line (HEK293) | Human | NEXN | 1:3~1:6 | Negative | Online Inquiry |
KO23426 | NEXN Knockout cell line (A549) | Human | NEXN | 1:3~1:4 | Negative | Online Inquiry |
NEXN Gene Knockout Cell Lines are genetically engineered cell lines in which the NEXN gene has been systematically disrupted or "knocked out" using advanced CRISPR-Cas9 gene editing techniques. These cell lines serve as critical tools for understanding the functional role of the NEXN protein, which is implicated in various cellular processes, including muscle contraction, tissue integrity, and potentially pathogenic pathways in diseases such as cardiomyopathies. By providing a context where the effects of the absence of the NEXN protein can be studied, these cell lines allow researchers to dissect cellular mechanisms and signaling pathways influenced by NEXN.
The primary function of NEXN Gene Knockout Cell Lines is to facilitate the study of gene function and its downstream effects on cell behavior. By deploying these cell lines in experimental setups, scientists can observe phenotypic changes, screen for small molecules, and elucidate pathways affected by the loss of NEXN activity. This makes the cell lines invaluable in both basic research and translational studies.
The scientific importance of NEXN Gene Knockout Cell Lines is underscored by their applications in elucidating the molecular bases of various diseases and identifying novel therapeutic targets. Researchers can utilize these models to explore the role of NEXN in disease mechanisms, providing insights that could lead to innovative treatment strategies. Clinical researchers can also use these cell lines for drug discovery and development, specifically to test compounds that modulate gene function or protein interactions.
One significant advantage of NEXN Gene Knockout Cell Lines is their precise genetic modification, which offers a level of specificity and control that traditional methods, such as RNA interference, cannot match. This precise knockout minimizes off-target effects and allows for more accurate data on gene function.
For researchers and clinicians, the availability of NEXN Gene Knockout Cell Lines means access to a robust model for investigating the contributions of the NEXN gene in both health and disease. The ease of use and versatility ensure that these cell lines can seamlessly integrate into diverse experimental designs, enhancing the speed and accuracy of research.
At our company, we pride ourselves on our expertise in genetic engineering and our commitment to providing high-quality biological products. Our NEXN Gene Knockout Cell Lines are developed with the highest standards in mind, equipping researchers with the essential tools they need to drive innovation across various scientific fields.
Please note that all services are for research use only. Not intended for any clinical use.
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