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NCAM1 Knockout Cell Lines

Gene: Ncam1

Official Full Name: neural cell adhesion molecule 1provided by MGI

Gene Summary: Predicted to enable LRR domain binding activity and phosphatase binding activity. Involved in commissural neuron axon guidance; epithelial to mesenchymal transition; and regulation of semaphorin-plexin signaling pathway. Acts upstream of or within several processes, including homotypic cell-cell adhesion; positive regulation of calcium-mediated signaling; and regulation of exocyst assembly. Located in several cellular components, including external side of plasma membrane; growth cone; and neuronal cell body. Is expressed in several structures, including embryo mesenchyme; genitourinary system; nervous system; sensory organ; and skin. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; bipolar disorder; drug dependence; middle cerebral artery infarction; and nicotine dependence. Orthologous to human NCAM1 (neural cell adhesion molecule 1). [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO09992 NCAM1 Knockout cell line (HEK293) Human NCAM1 1:3~1:6 Negative Online Inquiry

Background

Ncam1 Gene Knockout Cell Lines are specialized cellular models in which the Ncam1 gene, associated with neural cell adhesion molecule functionality, has been specifically inactivated to elucidate its biological role. These knockout cell lines serve as invaluable tools for studying the molecular mechanisms underlying neuronal processes, such as synaptic plasticity, cell migration, and differentiation, thereby providing insights into neural development and associated disorders.

The primary function of Ncam1 is to facilitate cell-cell interactions within the nervous system, influencing signaling pathways that are critical for neuronal communication. By knocking out the Ncam1 gene, researchers can investigate how the absence of this adhesion molecule affects neuronal behavior and culture conditions, leading to deeper understanding of neurodevelopmental mechanisms and potential therapeutic targets for neurodegenerative diseases and other neurological disorders.

The scientific importance of Ncam1 Gene Knockout Cell Lines lies in their applications across various research domains. They are particularly valuable in neurobiology, developmental biology, and cancer research, where understanding the dynamics of cell adhesion and signaling can provide insights into disease mechanisms. Moreover, these cell lines can be used in drug discovery efforts to assess the role of potential pharmacological agents on neural cell function.

What sets Ncam1 Gene Knockout Cell Lines apart from alternative cellular models is their specificity and genetic precision, which allow for controlled experiments that minimize confounding variables. These lines enable the study of gene function with greater accuracy, facilitating reproducible research outcomes and a better understanding of the complex interactions that drive neuronal behavior.

Researchers, clinicians, and pharmacologists will find these cell lines invaluable as they provide a robust platform for translating basic biological findings into clinical insights. Utilizing these sophisticated models not only enhances the quality of research data but also accelerates the development of innovative therapeutic strategies.

Our company prides itself on its commitment to advancing scientific research through the development and provision of high-quality biological products, including Ncam1 Gene Knockout Cell Lines. With our extensive expertise in genetic engineering and cell biology, we support the scientific community in driving breakthroughs that ultimately contribute to human health and knowledge.

Please note that all services are for research use only. Not intended for any clinical use.

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