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NAPSA Knockout Cell Lines

Gene: NAPSA

Official Full Name: napsin A aspartic peptidaseprovided by HGNC

Gene Summary: This gene encodes a member of the peptidase A1 family of aspartic proteases. The encoded preproprotein is proteolytically processed to generate an activation peptide and the mature protease. The activation peptides of aspartic proteinases function as inhibitors of the protease active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The encoded protease may play a role in the proteolytic processing of pulmonary surfactant protein B in the lung and may function in protein catabolism in the renal proximal tubules. This gene has been described as a marker for lung adenocarcinoma and renal cell carcinoma. [provided by RefSeq, Feb 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO33212 NAPSA Knockout cell line (HCT 116) Human NAPSA 1:2~1:4 Negative Online Inquiry
KO33213 NAPSA Knockout cell line (A549) Human NAPSA 1:3~1:4 Negative Online Inquiry

Background

NAPSA Gene Knockout Cell Lines are advanced cellular models specifically engineered to facilitate the study of the NAPSA gene (N-Acetylated alpha-linked acidic dipeptidase) and its functional roles in various biological processes. These cell lines are generated through CRISPR-Cas9 gene-editing technology, which allows for precise excision of the NAPSA gene, resulting in a complete knockout phenotype. The primary mechanism of action leverages indel mutations that disrupt the coding sequence of the gene, thereby allowing researchers to analyze the resultant cellular behaviors and compensatory pathways without the influence of NAPSA’s enzymatic activity.

The scientific importance of NAPSA gene knockout cell lines is highlighted in research settings focused on metabolic disorders, neurodegenerative diseases, and cancer, where NAPSA's function is often implicated. These models provide invaluable insights into the cellular mechanisms that accompany the loss of NAPSA, enabling scientists to explore gene-environment interactions and identify potential therapeutic targets. Additionally, the application of these cell lines in drug discovery and development can accelerate the identification of novel compounds that may modulate the NAPSA-related pathways.

What sets our NAPSA Gene Knockout Cell Lines apart from alternatives is the rigorous validation and characterization each line undergoes prior to release. Our state-of-the-art facility ensures that the knockouts are confirmed at both the genomic and phenotypic levels, providing unparalleled reliability for researchers. Additionally, the availability of ready-to-use cell lines reduces lead time for experiments, allowing for more efficient project timelines.

For researchers and clinicians alike, these cell lines offer a critical tool for advancing our understanding of NAPSA-related biology and its implications in health and disease. By employing our NAPSA Gene Knockout Cell Lines, users gain a depth of insight that can lead to significant scientific breakthroughs.

At our company, we pride ourselves on our extensive expertise in genetic engineering and cellular models, ensuring that each product we offer meets the highest standards of quality and rigor. Our commitment to supporting the scientific community is reflected in the innovative solutions we provide.

Please note that all services are for research use only. Not intended for any clinical use.

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