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NAGA Knockout Cell Lines

Gene: NAGA

Official Full Name: alpha-N-acetylgalactosaminidaseprovided by HGNC

Gene Summary: NAGA encodes the lysosomal enzyme alpha-N-acetylgalactosaminidase, which cleaves alpha-N-acetylgalactosaminyl moieties from glycoconjugates. Mutations in NAGA have been identified as the cause of Schindler disease types I and II (type II also known as Kanzaki disease). [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO36458 NAGA Knockout cell line (HeLa) Human NAGA 1:3~1:6 Negative Online Inquiry
KO36459 NAGA Knockout cell line (HCT 116) Human NAGA 1:2~1:4 Negative Online Inquiry
KO36460 NAGA Knockout cell line (HEK293) Human NAGA 1:3~1:6 Negative Online Inquiry
KO36461 NAGA Knockout cell line (A549) Human NAGA 1:3~1:4 Negative Online Inquiry

Background

NAGA Gene Knockout Cell Lines are genetically engineered cell models specifically designed to lack the expression of the N-acetylgalactosaminidase (NAGA) gene. This valuable research tool enables scientists to investigate the role of NAGA in various biological processes and disease mechanisms. By abolishing NAGA activity, researchers can gain insights into its involvement in glycosylation pathways, lysosomal storage disorders, and other metabolic functions.

The key function of NAGA gene knockout cell lines lies in their ability to simulate the absence of NAGA protein, allowing for detailed investigations into the gene's contributions to health and disease. These cell lines facilitate functional assays to elucidate pathway disruptions, enzymatic activities, and potential compensatory mechanisms that may arise due to the gene's absence. Researchers can employ these models in diverse contexts, from basic cellular bioscience to evaluating the efficacy of therapeutic targets in drug discovery.

The scientific importance of NAGA gene knockout cell lines is underscored by their applications in both laboratory research and clinical studies. These cell lines are instrumental in elucidating the underlying genetic and biochemical mechanisms of disorders related to glycosylation. Their utility extends to the pharmaceutical industry, where they can be used to screen for novel therapeutics aimed at correcting enzymatic deficiencies.

Compared to conventional methods of gene silencing or knockdown, NAGA gene knockout cell lines present a more stable and consistent model for long-term studies. They eliminate the variability often associated with transient knockdown approaches, offering researchers robust and reproducible data. Furthermore, the extensive characterization of these lines ensures confidence in their functional relevance and fidelity to human cellular behavior.

For researchers and clinicians alike, NAGA Gene Knockout Cell Lines represent a critical asset in advancing understandings of metabolic diseases and enhancing drug development pipelines. The adaptability and specificity of these cell lines make them indispensable for investigations into the therapeutic potential of modulating glycosylation pathways.

Our company prides itself on cutting-edge genetic engineering and cell line development, providing researchers with the high-quality tools necessary to advance biological science and healthcare innovations. With a commitment to excellence and a robust portfolio of products, we empower the scientific community to push the boundaries of discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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