Gene: MYO1E
Official Full Name: myosin IEprovided by HGNC
Gene Summary: This gene encodes a member of the nonmuscle class I myosins which are a subgroup of the unconventional myosin protein family. The unconventional myosin proteins function as actin-based molecular motors. Class I myosins are characterized by a head (motor) domain, a regulatory domain and a either a short or long tail domain. Among the class I myosins, this protein is distinguished by a long tail domain that is involved in crosslinking actin filaments. This protein localizes to the cytoplasm and may be involved in intracellular movement and membrane trafficking. Mutations in this gene are the cause of focal segmental glomerulosclerosis-6. This gene has been referred to as myosin IC in the literature but is distinct from the myosin IC gene located on chromosome 17. [provided by RefSeq, Jan 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO36504 | MYO1E Knockout cell line (HeLa) | Human | MYO1E | 1:3~1:6 | Negative | Online Inquiry |
KO36505 | MYO1E Knockout cell line (HCT 116) | Human | MYO1E | 1:2~1:4 | Negative | Online Inquiry |
KO36506 | MYO1E Knockout cell line (HEK293) | Human | MYO1E | 1:3~1:6 | Negative | Online Inquiry |
KO36507 | MYO1E Knockout cell line (A549) | Human | MYO1E | 1:3~1:4 | Negative | Online Inquiry |
MYO1E Gene Knockout Cell Lines are genetically modified cell lines specifically designed to lack the MYO1E gene, which encodes for the motor protein myosin IE. This gene is implicated in various cellular processes, including intracellular transport, cell motility, and membrane trafficking. By utilizing CRISPR-Cas9 technology, these knockout cell lines provide researchers with a powerful tool to study the functional roles of MYO1E in both normal physiology and cancer biology.
The primary mechanism of action involves the targeted disruption of the MYO1E gene, leading to a loss of protein function. This disruption allows for the observation of resultant phenotypic changes, offering insights into MYO1E's role in important cellular processes. Researchers can utilize these cell lines to investigate how the absence of MYO1E affects cellular behaviors such as adhesion, migration, and response to stimuli, which are critical in understanding various pathologies, particularly cancer metastasis.
In a research context, MYO1E Gene Knockout Cell Lines serve as valuable models that can facilitate the exploration of gene functions, the development of therapeutic targets, and the assessment of drug efficacy. Their applications span across fundamental research to clinical studies, making them relevant in both academic and commercial laboratories.
What distinguishes these knockout cell lines from traditional models is not only the precision of the gene editing accomplished through CRISPR-Cas9 but also the potential to rapidly generate various derivatives for specific research needs. They offer a cost-effective and time-efficient alternative to older methods of gene editing.
For researchers and clinicians aiming to deepen their understanding of myosin function and its implications in disease, MYO1E Gene Knockout Cell Lines are an invaluable asset. They exemplify a cutting-edge approach to elucidating complex biological mechanisms that contribute to human health.
As a company committed to advancing the life sciences, we leverage our expertise in genetic engineering to provide high-quality, reliable, and innovative products like MYO1E Gene Knockout Cell Lines, enabling research breakthroughs and empowering scientific discovery.
Please note that all services are for research use only. Not intended for any clinical use.
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