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MTA2 Knockout Cell Lines

Gene: MTA2

Official Full Name: metastasis associated 1 family member 2provided by HGNC

Gene Summary: This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis. [provided by RefSeq, May 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO33444 MTA2 Knockout cell line (HeLa) Human MTA2 1:3~1:6 Negative Online Inquiry
KO33445 MTA2 Knockout cell line (HCT 116) Human MTA2 1:2~1:4 Negative Online Inquiry
KO33446 MTA2 Knockout cell line (HEK293) Human MTA2 1:3~1:6 Negative Online Inquiry
KO33447 MTA2 Knockout cell line (A549) Human MTA2 1:3~1:4 Negative Online Inquiry

Background

MTA2 Gene Knockout Cell Lines are engineered cellular models that have had the MTA2 (Metastasis-Associated Protein 2) gene disrupted, facilitating in-depth studies of this crucial gene's role in cellular functions and disease mechanisms. MTA2 is known to participate in various biological processes, including chromatin remodeling and transcription regulation, which are pivotal in cancer metastasis, cellular proliferation, and differentiation. By using these knockout cell lines, researchers can observe the phenotypic and functional consequences of MTA2 gene ablation, thereby elucidating its pathways and potential therapeutic targets.

These cell lines work through the targeted deletion of the MTA2 gene, achieved via CRISPR-Cas9 technology, allowing for precise genetic modifications. Researchers can utilize these models to assess changes in cellular behavior, gene expression profiles, and protein interaction networks, offering insights that are critical for understanding tumorigenesis and developing novel cancer therapies.

The scientific importance of MTA2 Gene Knockout Cell Lines extends to various research avenues, particularly in cancer biology, pharmacology, and molecular genetics. They provide a valuable tool in drug discovery and the development of new treatments, enabling scientists to test hypotheses and validate targets in a controlled environment. In clinical settings, these models can highlight how MTA2 mutations or dysregulations contribute to cancer progression, potentially guiding personalized medicine approaches.

Compared to traditional cell lines that may retain functional MTA2, these knockout models offer clarity and specificity, helping to eliminate confounding variables in experimental data. Researchers can confidently attribute observed effects directly to the loss of MTA2 function. Furthermore, our MTA2 Gene Knockout Cell Lines are optimized for reproducibility and ease of use, ensuring consistent performance across experiments.

In summary, MTA2 Gene Knockout Cell Lines represent an invaluable resource for biomedical researchers and clinicians aiming to explore the multifaceted roles of MTA2 in health and disease. Our expertise in developing high-quality biological products ensures that our offerings meet the rigorous demands of contemporary scientific inquiry, empowering the advancement of knowledge and therapeutic innovation in the life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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