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MRPS22 Knockout Cell Lines

Gene: MRPS22

Official Full Name: mitochondrial ribosomal protein S22provided by HGNC

Gene Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that does not seem to have a counterpart in prokaryotic and fungal-mitochondrial ribosomes. This gene lies telomeric of and is transcribed in the opposite direction from the forkhead box L2 gene. A pseudogene corresponding to this gene is found on chromosome Xq. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO16037 MRPS22 Knockout cell line (HeLa) Human MRPS22 1:3~1:6 Negative Online Inquiry
KO16038 MRPS22 Knockout cell line (HCT 116) Human MRPS22 1:2~1:4 Negative Online Inquiry
KO16039 MRPS22 Knockout cell line (HEK293) Human MRPS22 1:3~1:6 Negative Online Inquiry

Background

MRPS22 Gene Knockout Cell Lines are a specialized research tool designed for the investigation of mitochondrial ribosomal proteins and their roles in cellular processes, particularly protein synthesis within the mitochondria. These engineered cell lines have undergone surgical gene editing to disrupt the expression of the MRPS22 gene, which encodes a crucial component of the mitochondrial ribosome, facilitating protein translation and subsequent energy production critical for cellular metabolism.

The primary function of the MRPS22 Gene Knockout Cell Lines resides in their ability to mimic specific genetic mutations, enabling researchers to study the functional consequences of MRPS22 loss. By utilizing these knockout models, scientists can elucidate the molecular mechanisms underlying mitochondrial dysfunction, which is often implicated in various diseases, including neurodegenerative disorders and metabolic syndromes. Additionally, these cell lines provide a platform for evaluating potential therapeutic interventions that target mitochondrial pathology.

The scientific importance of MRPS22 Gene Knockout Cell Lines extends beyond basic research; they are pivotal in drug screening, biomarker discovery, and the development of gene therapies aimed at restoring mitochondrial function. Compared to conventional cell lines, these knockout models offer a unique perspective into the repercussions of mitochondrial deficits, thus presenting more physiologically relevant data.

One of the significant advantages of MRPS22 Gene Knockout Cell Lines over alternative products is their precision and specificity. They allow for targeted exploration of mitochondrial processes without the confounding factors associated with other methods, such as whole-organism studies. For researchers and clinicians, this specificity can lead to more reliable data and accelerated project timelines.

In conclusion, the MRPS22 Gene Knockout Cell Lines represent a valuable asset for researchers exploring mitochondrial biology and related pathologies. Our company prides itself on delivering high-quality biological products that empower scientific discovery, and with extensive expertise in genetic engineering, we ensure each cell line meets rigorous standards to support your research needs effectively.

Please note that all services are for research use only. Not intended for any clinical use.

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