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MRM1 Knockout Cell Lines

Gene: MRM1

Official Full Name: mitochondrial rRNA methyltransferase 1provided by HGNC

Gene Summary: Enables rRNA (guanosine-2'-O-)-methyltransferase activity. Involved in rRNA processing. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO20908 MRM1 Knockout cell line (HeLa) Human MRM1 1:3~1:6 Negative Online Inquiry
KO20909 MRM1 Knockout cell line (HCT 116) Human MRM1 1:2~1:4 Negative Online Inquiry
KO20910 MRM1 Knockout cell line (HEK293) Human MRM1 1:3~1:6 Negative Online Inquiry
KO20911 MRM1 Knockout cell line (A549) Human MRM1 1:3~1:4 Negative Online Inquiry

Background

MRM1 Gene Knockout Cell Lines represent a pioneering tool in molecular biology research, designed to facilitate the investigation of mitochondrial ribosome biogenesis and the role of the MRM1 gene in cellular mechanisms. The generation of these knockout cell lines involves precise CRISPR-Cas9 gene editing technology, effectively disrupting the MRM1 gene. This targeted approach allows researchers to study the resultant phenotypic changes, mitochondrial function, and overall cellular metabolism without the confounding influences of MRM1 activity.

The mechanistic insight gained through the use of MRM1 knockout cell lines is invaluable. The MRM1 gene codes for a component of the mitochondrial ribosome, which is critical for protein synthesis within mitochondria, the energy powerhouses of the cell. By evaluating the effects of MRM1 disruption, researchers can elucidate its role in various biological processes, particularly those linked to mitochondrial disorders, aging, and metabolic diseases.

In clinical and research settings, these knockout cell lines have crucial applications, including drug discovery, disease modeling, and functional genomics analyses. Researchers studying mitochondrial-related pathologies and potential therapeutic interventions will find these cell lines indispensable due to their role in facilitating a deeper understanding of mitochondrial dynamics and gene function.

Compared to other gene knockout technologies, MRM1 Gene Knockout Cell Lines offer advantages such as enhanced specificity and efficiency of gene targeting. The use of state-of-the-art CRISPR-Cas9 methods ensures precise edits with minimal off-target effects, resulting in reliable data for downstream applications.

For researchers and clinicians alike, the value of MRM1 Gene Knockout Cell Lines lies in their ability to unlock new insights into mitochondrial biology, allowing for more effective therapeutic strategies and contributing to the advancement of personalized medicine. Our company, renowned for its expertise in the field of genetic engineering and custom cell line development, is dedicated to providing high-quality, scientifically validated products that empower the research community and accelerate discoveries in health and disease.

Please note that all services are for research use only. Not intended for any clinical use.

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