Gene: MLLT3
Official Full Name: MLLT3 super elongation complex subunitprovided by HGNC
Gene Summary: Enables chromatin binding activity; lysine-acetylated histone binding activity; and molecular adaptor activity. Involved in several processes, including hematopoietic stem cell differentiation; positive regulation of DNA-templated transcription; and regulation of stem cell division. Acts upstream of or within negative regulation of canonical Wnt signaling pathway and positive regulation of Wnt signaling pathway, planar cell polarity pathway. Located in cytosol and nucleoplasm. Part of transcription elongation factor complex. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO02875 | MLLT3 Knockout cell line (HeLa) | Human | MLLT3 | 1:3~1:6 | Negative | Online Inquiry |
KO02876 | MLLT3 Knockout cell line (HCT 116) | Human | MLLT3 | 1:2~1:4 | Negative | Online Inquiry |
KO02877 | MLLT3 Knockout cell line (HEK293) | Human | MLLT3 | 1:3~1:6 | Negative | Online Inquiry |
KO02878 | MLLT3 Knockout cell line (A549) | Human | MLLT3 | 1:3~1:4 | Negative | Online Inquiry |
MLLT3 Gene Knockout Cell Lines are specialized cell models developed through precise gene-editing techniques to specifically disable the MLLT3 gene, which plays a significant role in various cellular processes, including transcriptional regulation and gene expression. This knockout approach enables researchers to investigate the downstream effects of MLLT3 loss, thereby elucidating its biological functions in healthy and diseased states.
These cell lines operate on distinct mechanisms that involve the disruption of MLLT3’s interactions with key molecular partners, such as histone methyltransferases. This disruption has profound implications for cellular pathways regulating cell proliferation, differentiation, and apoptosis. By studying MLLT3 knockout cells, researchers can gain insights into its role in oncogenesis, as aberrations in this gene have been implicated in several cancers, including acute myeloid leukemia (AML) and other hematological malignancies.
The scientific importance of MLLT3 Gene Knockout Cell Lines lies in their utility as robust tools for investigating disease mechanisms and screening therapeutic candidates. They offer vast potential for drug discovery and development, allowing for high-throughput screening of compounds aimed at modulating pathways influenced by MLLT3. In clinical settings, understanding the behavior of these knockout lines can assist in the identification of biomarkers for patient stratification and targeted therapies.
Compared to alternative models, MLLT3 Gene Knockout Cell Lines are distinct in their specificity and fidelity. Other methods of gene manipulation often result in partial loss of function or unintended off-target effects, whereas our knockout cell lines provide a clean and reproducible model for studying MLLT3’s effects without these confounding variables. This purity enhances the reliability of experimental results, making the findings more translatable to human health applications.
For researchers and clinicians, investing in MLLT3 Gene Knockout Cell Lines extends beyond studying a single gene; it opens avenues to unravel complex biological networks and provides hope for therapeutic advancements. Our commitment to cutting-edge technology and high-quality biological products is rooted in our team’s extensive experience in genetic engineering and cell line development, ensuring researchers have access to reliable resources for their research needs.
Please note that all services are for research use only. Not intended for any clinical use.
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