Gene: MKI67
Official Full Name: marker of proliferation Ki-67provided by HGNC
Gene Summary: Enables RNA binding activity and molecular condensate scaffold activity. Involved in chromosome segregation and regulation of mitotic nuclear division. Located in chromosome; nuclear body; and nucleolus. Is active in condensed chromosome. Implicated in several diseases, including Crohn's disease; colorectal cancer; endocrine gland cancer (multiple); graft-versus-host disease; and human immunodeficiency virus infectious disease. Biomarker of several diseases, including Barrett's esophagus; autoimmune disease of musculoskeletal system (multiple); endocrine gland cancer (multiple); gastrointestinal system cancer (multiple); and lung cancer (multiple). [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO16151 | MKI67 Knockout cell line (HCT 116) | Human | MKI67 | 1:2~1:4 | Negative | Online Inquiry |
KO16152 | MKI67 Knockout cell line (HEK293) | Human | MKI67 | 1:3~1:6 | Negative | Online Inquiry |
KO39178 | MKI67 Knockout cell line (HeLa) | Human | MKI67 | 1:3~1:6 | Negative | Online Inquiry |
MKI67 Gene Knockout Cell Lines represent a significant advancement in cellular biology research, specifically designed to study the role of the MKI67 gene in cell proliferation and cancer development. MKI67 encodes a protein associated with cellular proliferation, making these knockout cell lines invaluable tools for investigating how alterations in cell growth contribute to tumorigenesis and various diseases characterized by abnormal cell division.
The primary function of MKI67 Gene Knockout Cell Lines is to enable researchers to assess the phenotypic consequences of the absence of the MKI67 protein. By creating a targeted disruption of this gene, scientists can elucidate its essential role in the cell cycle and identify signaling pathways impacted by its knockout. This elucidation is crucial not only for understanding fundamental biological processes but also for developing novel therapeutic strategies aimed at targeting cancer cell proliferation.
The scientific importance of these cell lines extends to both research and clinical applications, including drug testing, gene therapy, and personalized medicine approaches. By utilizing MKI67 knockout cell lines, researchers can perform high-throughput screening for compounds that selectively affect cancerous cells while sparing normal ones, potentially leading to safer treatment options.
What sets MKI67 Gene Knockout Cell Lines apart from other models is their precise gene editing, ensuring reliable and reproducible results that are critical for publication and translational research. These cells offer enhanced specificity and sensitivity in experiments, ultimately providing deeper insights into the molecular mechanisms of disease.
For researchers and clinicians aiming to push the boundaries of current scientific knowledge or develop breakthrough therapies, MKI67 Gene Knockout Cell Lines serve as a crucial asset. Their unique capabilities help advance our understanding of cellular behaviors in health and disease.
At [Your Company Name], we are dedicated to providing high-quality biological products that empower scientific discovery. Our expertise in gene editing and cellular models ensures that you receive reliable tools necessary for groundbreaking research and clinical applications.
Please note that all services are for research use only. Not intended for any clinical use.
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