Gene: MICAL3
Official Full Name: microtubule associated monooxygenase, calponin and LIM domain containing 3provided by HGNC
Gene Summary: Enables actin binding activity and molecular adaptor activity. Involved in actin filament depolymerization. Located in several cellular components, including Flemming body; intercellular bridge; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO16182 | MICAL3 Knockout cell line (HeLa) | Human | MICAL3 | 1:3~1:6 | Negative | Online Inquiry |
KO16183 | MICAL3 Knockout cell line (HCT 116) | Human | MICAL3 | 1:2~1:4 | Negative | Online Inquiry |
KO16184 | MICAL3 Knockout cell line (HEK293) | Human | MICAL3 | 1:3~1:6 | Negative | Online Inquiry |
KO16185 | MICAL3 Knockout cell line (A549) | Human | MICAL3 | 1:3~1:4 | Negative | Online Inquiry |
MICAL3 Gene Knockout Cell Lines are genetically modified cell lines designed to specifically disrupt the MICAL3 gene, which encodes for a protein involved in regulating cellular oxidative stress and actin dynamics. These knockout cell lines utilize CRISPR-Cas9 technology to create precise deletions in the MICAL3 gene, enabling researchers to investigate its biological functions and explore the implications of its absence on various cellular processes.
The primary function of MICAL3 involves mediating cytoskeletal reorganization and influencing signaling pathways associated with cell motility and morphology. By studying these knockout cell lines, scientists can glean vital insights into the regulatory mechanisms governed by MICAL3, particularly its impact on neuronal development, immune responses, and tumor progression. These cell lines serve as invaluable tools for elucidating the molecular underpinnings of diseases wherein oxidative stress plays a pivotal role, such as neurodegenerative diseases and cancer.
A significant advantage of MICAL3 Gene Knockout Cell Lines is the precision and specificity offered by the CRISPR-Cas9 editing system, which minimizes off-target effects commonly associated with traditional knockout methodologies. This precision allows for high reproducibility and reliability in experimental outcomes. Additionally, the availability of these cell lines facilitates time-efficient screening processes for pharmacological agents aimed at modulating MICAL3-related pathways, thus accelerating drug discovery efforts.
For researchers and clinicians, utilizing MICAL3 Gene Knockout Cell Lines means access to a robust platform for identifying novel therapeutic targets and understanding disease mechanisms on a molecular level. The ability to conduct targeted studies on the role of MICAL3 not only enriches the foundational knowledge in cellular biology but also has potential translational applications in developing innovative therapeutic strategies.
Our company boasts a rich portfolio of cutting-edge genetic engineering solutions, coupled with extensive expertise in molecular biology, ensuring that users of MICAL3 Gene Knockout Cell Lines receive unparalleled support and guidance throughout their research endeavors. By choosing our product, researchers align themselves with a leader in the field of genetic cell line development, setting the stage for breakthroughs in biological and biomedical research.
Please note that all services are for research use only. Not intended for any clinical use.
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