Gene: MDFI
Official Full Name: MyoD family inhibitorprovided by HGNC
Gene Summary: This protein is a transcription factor that negatively regulates other myogenic family proteins. Studies of the mouse homolog, I-mf, show that it interferes with myogenic factor function by masking nuclear localization signals and preventing DNA binding. Knockout mouse studies show defects in the formation of vertebrae and ribs that also involve cartilage formation in these structures. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO36691 | MDFI Knockout cell line (HCT 116) | Human | MDFI | 1:2~1:4 | Negative | Online Inquiry |
MDFI Gene Knockout Cell Lines are sophisticated biological tools engineered to facilitate the study of gene function and disease mechanisms. Created through advanced CRISPR-Cas9 technology, these cell lines enable researchers to create defined gene disruptions, allowing for targeted investigations into the role of specific genes in various biological processes. Each cell line is designed meticulously by knocking out MDFI (Myeloid Differentiation Factor 1), a gene implicated in immune response and cell differentiation, making it a valuable asset for both basic and translational research.
The primary mechanism of action involves the site-specific editing of the genome, where the CRISPR-Cas9 complex introduces double-strand breaks at designated loci, leading to frameshift mutations upon repair. This targeted knockout allows for the assessment of functional changes in pathways influenced by MDFI, which is especially crucial for understanding its contribution to hematopoiesis and immunological diseases.
In scientific research and clinical applications, MDFI Gene Knockout Cell Lines serve as pivotal platforms for screening potential therapeutics, elucidating gene pathways, and modeling diseases such as leukemia and other hematological disorders. By providing an in vitro environment that simulates the genetic aberrations seen in patient samples, these cell lines contribute significantly to the advancement of personalized medicine strategies.
What sets MDFI Gene Knockout Cell Lines apart from alternative models is their precise genetic modification, ensuring reproducibility and reliability in experimental outcomes. Unlike conventional cell lines that may harbor unknown genetic variations, MDFI knockouts offer consistency and specificity, enhancing data relevance and interpretability.
For researchers and clinicians, these cell lines represent an invaluable resource for studying gene function and developing novel treatment pathways. By understanding gene interactions and regulatory mechanisms, users can drive discoveries that have the potential to transform therapeutic approaches.
Our company specializes in developing high-quality biological products, underscored by our commitment to scientific excellence and innovation. Through rigorous testing and validation, we ensure that our MDFI Gene Knockout Cell Lines meet the highest standards, equipping researchers with the tools necessary to advance their scientific inquiries and improving patient outcomes.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.