Gene: MBD3
Official Full Name: methyl-CpG binding domain protein 3provided by HGNC
Gene Summary: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. This gene belongs to a family of nuclear proteins which are characterized by the presence of a methyl-CpG binding domain (MBD). The encoded protein is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. Unlike the other family members, the encoded protein is not capable of binding to methylated DNA. The protein mediates the association of metastasis-associated protein 2 with the core histone deacetylase complex. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO21934 | MBD3 Knockout cell line (HeLa) | Human | MBD3 | 1:3~1:6 | Negative | Online Inquiry |
KO21935 | MBD3 Knockout cell line (HCT 116) | Human | MBD3 | 1:2~1:4 | Negative | Online Inquiry |
KO21936 | MBD3 Knockout cell line (HEK293) | Human | MBD3 | 1:3~1:6 | Negative | Online Inquiry |
KO21937 | MBD3 Knockout cell line (A549) | Human | MBD3 | 1:3~1:4 | Negative | Online Inquiry |
MBD3 Gene Knockout Cell Lines are genetically engineered cells that have had the MBD3 gene silenced, allowing researchers to study the role of MBD3 in cellular processes more effectively. MBD3, a component of the NuRD (Nucleosome Remodeling and Deacetylation) complex, plays a crucial role in gene regulation and chromatin remodeling. By utilizing these knockout cell lines, scientists can investigate the implications of MBD3 loss on various cellular functions, including differentiation, proliferation, and response to stress, elucidating its significance in cancer biology and developmental studies.
The key mechanism of action involves the absence of MBD3, which alters the chromatin landscape and ultimately affects gene expression patterns. This alteration enables researchers to discern the downstream effects of disrupted gene regulation, providing insights into the molecular pathways involved in diseases such as cancer, where MBD3 expression is often abnormal. The implications of MBD3 in epigenetic regulation make these knockout cell lines an essential tool for both basic research and therapeutic development.
MBD3 Gene Knockout Cell Lines stand out due to their high specificity and reliability compared to other gene-editing tools, such as CRISPR or RNAi methods, which may inadvertently affect off-target genes. This specificity ensures that experimental results are more straightforward to interpret and replicate, minimizing confounding variables. Researchers benefit from the ease of use and robust physiological relevance, enabling a more seamless integration into existing experimental models.
Investing in MBD3 Gene Knockout Cell Lines allows researchers and clinicians to conduct detailed studies into gene functionality and regulatory mechanisms that are critical in various biomedical fields. By providing access to well-characterized and validated cell lines, your research can lead to advancements in understanding complex biological processes, fostering innovation in gene therapy and targeted treatments.
Our company prides itself on providing high-quality biological products accompanied by expert support. With a commitment to advancing scientific discovery, we equip researchers with tools that enhance their investigations and facilitate groundbreaking findings in the life sciences.
Please note that all services are for research use only. Not intended for any clinical use.
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