Gene: MAPKAPK5
Official Full Name: MAPK activated protein kinase 5provided by HGNC
Gene Summary: The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO10619 | MAPKAPK5 Knockout cell line (HeLa) | Human | MAPKAPK5 | 1:3~1:6 | Negative | Online Inquiry |
KO10620 | MAPKAPK5 Knockout cell line (HCT 116) | Human | MAPKAPK5 | 1:2~1:4 | Negative | Online Inquiry |
KO10621 | MAPKAPK5 Knockout cell line (HEK293) | Human | MAPKAPK5 | 1:3~1:6 | Negative | Online Inquiry |
KO10622 | MAPKAPK5 Knockout cell line (A549) | Human | MAPKAPK5 | 1:3~1:4 | Negative | Online Inquiry |
MAPKAPK5 Gene Knockout Cell Lines are engineered cellular models designed to facilitate the study of the MAPKAPK5 gene, a crucial component of the mitogen-activated protein kinase (MAPK) signaling pathways. These knockout cell lines are generated through advanced CRISPR/Cas9 technology, effectively disabling the functionality of the MAPKAPK5 gene, thereby allowing researchers to investigate the specific biological roles and downstream effects associated with its absence.
Key functions of the MAPKAPK5 protein include its involvement in cellular stress responses, immune response regulation, and cell proliferation. Its mechanism of action encompasses phosphorylation of downstream target proteins that mediate several signaling cascades, particularly those relevant to tumorigenesis and inflammatory processes. By utilizing these knockout cell lines, researchers can dissect the contributions of MAPKAPK5 to various physiological and pathophysiological conditions, enhancing our understanding of cancer biology, neurodegenerative diseases, and other health issues relevant to human well-being.
The scientific importance of MAPKAPK5 Gene Knockout Cell Lines extends beyond basic research; they are invaluable in drug discovery and development, providing a platform for screening therapeutic agents that target related signaling pathways. In clinical settings, these models can help elucidate patient-specific responses to therapies by revealing the complexities of gene interactions in cancer and other diseases.
One of the primary advantages of our MAPKAPK5 Gene Knockout Cell Lines is their specificity and reliability. Compared to other gene editing approaches, CRISPR/Cas9 allows precise modifications with minimal off-target effects, ensuring that any observed phenotypic changes are due to the gene knockout itself. This increases the confidence in experimental outcomes and accelerates the pace of biomedical research.
For researchers and clinicians alike, access to MAPKAPK5 Gene Knockout Cell Lines offers an opportunity to unlock novel insights into the mechanistic underpinnings of disease and treatment responses. Our company has a proven track record in producing high-quality biological products, and we are committed to advancing scientific endeavors through innovative solutions that empower the research community. By choosing our products, you can enhance the depth and accuracy of your investigations into critical cellular mechanisms.
Please note that all services are for research use only. Not intended for any clinical use.
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